3G2S: VHS Domain of human GGA1

VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide. Determined by X-ray diffraction at 1.7 Å resolution. Released 15 Dec 2009.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,785
Mol. weight: 36.76 kDa
Ligands: HEZ
Released: 15 Dec 2009

Explore 3G2S in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3G2S contains 22 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	7-9	3
α-helix	10-17	8
α-helix	27-36	10
α-helix	37-39	3
α-helix	43-55	13
α-helix	60-76	17
α-helix	79-85	7
α-helix	88-98	11
α-helix	104-106	3
α-helix	109-125	17
α-helix	130-141	12

Chain B: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	10-17	8
α-helix	27-37	11
α-helix	43-55	13
α-helix	60-76	17
α-helix	79-85	7
α-helix	88-98	11
α-helix	104-106	3
α-helix	109-125	17
α-helix	130-141	12

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-12	4

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-12	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ADP-ribosylation factor-binding protein GGA1	A, B	protein	149	Homo sapiens	Q9UJY5 (AlphaFold model)
C-terminal fragment of Sortilin-related receptor	C, D	protein	13		Q92673 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3G2S_1 ADP-ribosylation factor-binding protein GGA1 (chains A, B)
GSMEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSP
QEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILEL
LYSWTVGLPEEVKIAEAYQMLKKQGIVKS

Sequence of entity 2 (C, D), FASTA

>3G2S_2 C-terminal fragment of Sortilin-related receptor (chains C, D)
ITGFSDDVPMVIA

Ligands and cofactors

ID	Name	Formula	Copies
HEZ	Hexane-1,6-diol	C6 H14 O2	1

Primary citation

GGA autoinhibition revisited. Cramer, J.F., Gustafsen, C., Behrens, M.A. et al. Traffic (2010) 11:259-273. DOI 10.1111/j.1600-0854.2009.01017.x · PubMed

Other PDB entries of the same protein (UniProt Q9UJY5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1J2J 1.6 Å, Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form
1UJK 1.9 Å, VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE
1JWG 2.0 Å, VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide
3G2T 2.0 Å, VHS Domain of human GGA1 complexed with SorLA C-terminal Phosphopeptide
1JWF 2.1 Å, Crystal Structure of human GGA1 VHS domain.
1O3X 2.1 Å, Crystal structure of human GGA1 GAT domain
3G2V 2.1 Å, VHS Domain of human GGA1 complexed with Sotilin C-terminal Phosphopeptide
1NA8 2.3 Å, Crystal structure of ADP-ribosylation factor binding protein GGA1
2DWY 2.3 Å, Crystal Structure Analysis of GGA1-GAE
3G2U 2.3 Å, VHS Domain of human GGA1 complexed with Sotilin C-terminal Peptide
1NWM 2.4 Å, GAT domain of human GGA1
3G2W 2.4 Å, VHS Domain of human GGA1 complexed with a DXXLL hinge peptide

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