KiSS-1 receptor (KISS1R) is a 398-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q969F8.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:11457843, PubMed:11527393, PubMed:15020672, PubMed:15596153). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:12944565, PubMed:14573733, PubMed:15598687, PubMed:17164310, PubMed:18272894). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:14573733,…
Interacts with SRC and DUSP18; the interaction depends on receptor activation by kisspeptin-10 and is required for DUSP18-mediated dephosphorylation of SRC (PubMed:38346942). Interaction with SRC and DUSP18 is relevant for down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8XGO | EM | 2.68 Å | A=1-398 |
| 8XGS | EM | 2.95 Å | A=1-398 |
| 8XGU | EM | 3.0 Å | A=1-398 |
| 8ZJD | EM | 3.06 Å | R=2-355 |
| 8ZJE | EM | 3.07 Å | R=1-398 |
| 7YQE | X-ray | 3.5 Å | A/B=333-357 |
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