Ubiquitin thioesterase otulin (OTULIN) is a 352-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96BN8.
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The mean pLDDT of this model is 83.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843,…
Interacts (via the PUB domain) with RNF31 (via the PIM motif); the interaction is direct (PubMed:23708998, PubMed:23746843, PubMed:24726323, PubMed:24726327, PubMed:27523608). Interacts with DVL2 (By similarity)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3ZNV | X-ray | 1.3 Å | A=80-352 |
| 3ZNX | X-ray | 1.35 Å | A=80-352 |
| 4KSJ | X-ray | 1.6 Å | A=79-352 |
| 6I9C | X-ray | 1.77 Å | A=80-345 |
| 3ZNZ | X-ray | 1.9 Å | A=80-352 |
| 4OYK | X-ray | 2.0 Å | C/D=49-67 |
| 6SAK | X-ray | 2.0 Å | A/B=80-352 |
| 9LZX | X-ray | 2.0 Å | A=80-345 |
| 4KSK | X-ray | 2.4 Å | A/B=55-352 |
| 4P0B | X-ray | 2.7 Å | B/D=52-61 |
| 4KSL | X-ray | 2.83 Å | A/B/E/G/I/K/M/O/Q/S/U/W=79-352 |
| 5OE7 | X-ray | 2.95 Å | A=80-350 |
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