Q96DX5: Ankyrin repeat and SOCS box protein 9 (ASB9)

Ankyrin repeat and SOCS box protein 9 (ASB9) is a 294-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96DX5.

Gene
ASB9
Organism
Homo sapiens
Length
294 residues
Mean pLDDT
91.5
Model
AF-Q96DX5-F1 v6
Model created
1 Aug 2025
PDB structures
4

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Model confidence (pLDDT)

The mean pLDDT of this model is 91.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate83%
70 to 90Confident: backbone generally right10%
50 to 70Low: treat with caution1%
Below 50Very low: often disordered regions6%

What pLDDT means and how to read it

Function

Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465)

Subunit structure

Substrate-recognition component of the ECS(ASB9) complex, composed of ASB9, CUL5, ELOB, ELOC and RNF7/RBX2

Subcellular location

Mitochondrion

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
3D9HX-ray2.2 ÅA=1-254
3ZKJX-ray2.58 ÅA/D=35-294
3ZNGX-ray2.85 ÅA/D=35-294
6V9HEM4.1 ÅC=1-294

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