Ubiquitin thioesterase OTUB1 (OTUB1) is a 271-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96FW1.
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The mean pLDDT of this model is 91.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020).…
Interacts with FUS and RACK1 (PubMed:18954305). Interacts with UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13 (PubMed:20725033, PubMed:22325355, PubMed:22367539, PubMed:35927303)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2ZFY | X-ray | 1.69 Å | A=40-271 |
| 4LDT | X-ray | 1.9 Å | A=1-48 |
| 4I6L | X-ray | 2.49 Å | A=45-271 |
| 4DHZ | X-ray | 3.11 Å | A=1-48 |
| 3VON | X-ray | 3.15 Å | A/H/O/V/c/j=45-271 |
| 4DDG | X-ray | 3.3 Å | A/B/C/J/K/L=25-271 |
| 4DDI | X-ray | 3.8 Å | A/B/C=25-271 |
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