Tonsoku-like protein (TONSL) is a 1378-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96HA7.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex…
Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2 (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:27338793). Interacts with the MCM complex, the FACT complex and the RPA complex (PubMed:21055983, PubMed:21055984, PubMed:26527279). Interacts with MCM5; the interaction is direct (PubMed:26527279). Binds histones, with a…
Nucleus, Chromosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9WVH | X-ray | 1.96 Å | A/B=933-1011 |
| 9WVI | X-ray | 2.19 Å | A/B/C/D=933-1011 |
| 5JA4 | X-ray | 2.42 Å | D=512-692 |
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