Kremen protein 1 (KREMEN1) is a 473-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96MU8.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification
Forms a ternary complex with DKK1 and LRP6 (PubMed:27524201). Interacts with LRP6 in a DKK1-dependent manner. Interacts with DKK1 and RSPO1 (via FU repeats) (PubMed:17804805)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FWS | X-ray | 1.9 Å | A=29-373 |
| 5FWT | X-ray | 2.1 Å | A=29-373 |
| 9VFR | EM | 2.55 Å | G=30-322 |
| 5FWU | X-ray | 2.8 Å | A=29-373 |
| 7BZT | EM | 3.0 Å | E=23-375 |
| 7BZU | EM | 3.0 Å | E=23-375 |
| 5FWV | X-ray | 3.2 Å | A=29-373 |
| 5FWW | X-ray | 3.5 Å | B=30-322 |
| 6SNW | EM | 3.9 Å | E=23-324, E=326-373 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.