NADPH oxidase 5 (NOX5) is a 765-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96PH1.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). Also synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (PubMed:34784249). May play a role in cell growth and apoptosis (PubMed:12686516)
Homooligomer
Endoplasmic reticulum, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6SZ5 | X-ray | 2.23 Å | B/C=19-765 |
| 8U85 | EM | 3.2 Å | A/C=19-765 |
| 8U86 | EM | 3.3 Å | A/C=19-765 |
| 8U87 | EM | 3.86 Å | A/C=19-765 |
| 8U7Y | EM | 4.06 Å | A/B=19-765 |
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