Rho GTPase-activating protein 7 (DLC1) is a 1528-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96QB1.
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The mean pLDDT of this model is 55.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and…
Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration (PubMed:19158340). Interacts with tensin TNS1 (via N-terminus); the interaction is decreased by phosphorylation of TNS1 (PubMed:19826001, PubMed:20798394, PubMed:26427649). Interacts with TNS3 and PTEN; in resting cells, interacts with TNS3 (via…
Cytoplasm, Cell junction, focal adhesion, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FZT | X-ray | 2.1 Å | B=904-926 |
| 3KUQ | X-ray | 2.3 Å | A=1074-1283 |
| 7TPB | X-ray | 3.2 Å | B/D/F/H=1074-1283 |
| 2DKY | NMR | A=449-515 | |
| 2GYT | NMR | A=449-513 | |
| 2KAP | NMR | A=454-513 | |
| 2LOZ | NMR | B=811-824 |
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