Viral macrophage inflammatory protein 2 (ORF K4) is a 94-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q98157.
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The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Viral CC chemokine that binds to a broad spectrum of viral and human chemokine receptors and, depending on the receptor, acts either as an antagonist or an agonist. Capable of binding to chemokine receptors of the 4 families (CCR, CXCR, XCR, and CX3CR). Acts as an antagonist toward CCR1, CCR2, CCR5, and CCR10, competing with the endogenous chemokine binding and signaling (PubMed:9287217). On the other hand, acts as an agonist of CCR3 and CCR8, triggering G protein-mediated intracellular calcium release and activation of the ERK and PI3K/AKT signaling pathways, or chemotaxis (PubMed:9323208, PubMed:9834206, PubMed:11500830). Thereby, participates in the skewing of the host immune system…
Monomer. Interacts with human chemokine receptor CXCR4 (PubMed:25612609). Interacts with host CCR3 (PubMed:9323208, PubMed:11500830). Interacts with host CCR8 (PubMed:9834206). Interacts with host CCR1, CCR2 and CCR5 (PubMed:9287217). Interacts with ACKR3/CXCR7; this interaction regulates vCCL2 availability and activity toward human receptors (PubMed:27238288)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2FHT | X-ray | 1.7 Å | A=24-94 |
| 1CM9 | X-ray | 2.1 Å | A/B=21-94 |
| 2FJ2 | X-ray | 2.3 Å | A/B/C/D=24-94 |
| 4RWS | X-ray | 3.1 Å | C=24-94 |
| 1HFF | NMR | A=24-33 | |
| 1HFG | NMR | A=24-94 | |
| 1HFN | NMR | A=24-94 | |
| 1HHV | NMR | A=21-94 | |
| 1VMP | NMR | A=24-94 |
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