Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a 626-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99759.
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The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators
Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2C60 | X-ray | 1.25 Å | A=27-124 |
| 2O2V | X-ray | 1.83 Å | B=36-124 |
| 4YL6 | X-ray | 2.1 Å | B=1-22 |
| 4Y5O | X-ray | 2.35 Å | B=1-124 |
| 2JRH | NMR | A=42-126 | |
| 2PPH | NMR | A=42-126 |
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