RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1) is a 238-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BSD3.
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The mean pLDDT of this model is 64.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 40% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37440612). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase (PubMed:37440612). Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair (PubMed:37440612). Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase (PubMed:21659603,…
Interacts (when phosphorylated by PLK1) with POLQ; promoting POLQ recruitment to DNA damage sites (PubMed:37440612). Interacts with RAD1; interaction is direct and promotes association with the 9-1-1 (RAD9-RAD1-HUS1) complex (PubMed:31776186). Interacts with RAD18 (PubMed:21659603). Interacts with TOPBP1 (PubMed:21659603, PubMed:25602520). Interacts with UBE2N (PubMed:21659603)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
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