Centromere protein O (CENPO) is a 300-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BU64.
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The mean pLDDT of this model is 85.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU
Nucleus, Chromosome, centromere, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7R5S | EM | 2.83 Å | O=1-300 |
| 7PKN | EM | 3.2 Å | O=1-300 |
| 7XHO | EM | 3.29 Å | O=1-300 |
| 7PB8 | X-ray | 3.68 Å | O=1-300 |
| 7XHN | EM | 3.71 Å | O/o=1-300 |
| 7R5V | EM | 4.55 Å | O=1-300 |
| 7QOO | EM | 4.6 Å | O=1-300 |
| 7YYH | EM | 8.9 Å | O=1-300 |
| 7YWX | EM | 12.0 Å | O=1-300 |
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