Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) is a 581-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BXM7.
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The mean pLDDT of this model is 77.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress (PubMed:40080546). It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). In healthy mitochondria,…
Upon mitochondrial depolarization, associates with the TOM complex and the VDAC2 homodimer; its import into the mitochondria is stalled at the TOM complex (PubMed:40080546). Upon mitochondrial depolarization, interacts with TIMM23 (PubMed:38416681). Forms a supercomplex with TOM and TIM23 complexes; PINK1-TOM-TIM23 supercomplex formation requires PINK1 interaction with TOMM20 and TOMM70…
Mitochondrion outer membrane, Mitochondrion inner membrane, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9EII | EM | 2.75 Å | B=1-581 |
| 9KQN | EM | 2.84 Å | C=110-581 |
| 9KMR | EM | 2.98 Å | C=1-581 |
| 9EIH | EM | 3.1 Å | A/B=1-581 |
| 9EIJ | EM | 3.3 Å | B=1-581 |
| 9KOX | EM | 4.43 Å | C=110-581 |
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