RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a 510-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BYM8.
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The mean pLDDT of this model is 84.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173,…
Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22430200, PubMed:28481331). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). Interacts…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8K6Q | X-ray | 1.59 Å | A/B/C/D=1-51 |
| 9EGW | X-ray | 1.78 Å | A/B=425-510 |
| 7YUJ | X-ray | 1.86 Å | A/B=365-510 |
| 7V8E | X-ray | 1.9 Å | C/D=53-135 |
| 9EGV | X-ray | 2.0 Å | A/B=425-510 |
| 8BVL | X-ray | 2.24 Å | A/B=368-510 |
| 7YUI | X-ray | 2.6 Å | B=195-424 |
| 4DBG | X-ray | 2.71 Å | A=37-137 |
| 8EAZ | X-ray | 3.08 Å | A/B=232-510 |
| 2CRC | NMR | A=194-232 | |
| 2LGY | NMR | A=51-139 |
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