Histone-lysine N-methyltransferase NSD3 (NSD3) is a 1437-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BZ95.
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The mean pLDDT of this model is 61.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression
Interacts with BRD4 (PubMed:21555454, PubMed:29176719). Interacts (via KIKL motif) with BRD3 (via NET domain) (PubMed:29567837, PubMed:33592170)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6G25 | X-ray | 1.43 Å | A=263-398 |
| 4GNE | X-ray | 1.47 Å | A=1310-1413 |
| 4GNF | X-ray | 1.55 Å | A=1310-1413 |
| 6CEN | X-ray | 1.61 Å | A=1058-1285 |
| 6G2B | X-ray | 1.61 Å | A=263-398 |
| 6G27 | X-ray | 1.65 Å | A=263-398 |
| 6G29 | X-ray | 1.7 Å | A=263-398 |
| 4GNG | X-ray | 1.73 Å | A/D=1310-1413 |
| 6G2F | X-ray | 1.74 Å | A=263-398 |
| 6G2C | X-ray | 1.76 Å | A=263-398 |
| 5UPD | X-ray | 1.8 Å | A=1054-1285 |
| 6G2O | X-ray | 1.81 Å | A=263-398 |
| 6G2E | X-ray | 1.85 Å | A=263-398 |
| 4RXJ | X-ray | 2.1 Å | A=953-1064 |
| 6G24 | X-ray | 2.1 Å | A=263-398 |
| 4GND | X-ray | 2.27 Å | A/C=1310-1413 |
| 6G3T | X-ray | 2.53 Å | A/B/C/D=247-398 |
| 6G3P | X-ray | 2.8 Å | A/B/C/D=247-398 |
| 7CRQ | EM | 3.15 Å | I/L=680-1437 |
| 7CRP | EM | 3.2 Å | I=680-1437 |
Showing 20 of 25 experimental structures (best resolution first).
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