Phosphatase and actin regulator 1 (PHACTR1) is a 580-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9C0D0.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 62.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity)
Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site
Cytoplasm, Synapse, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ZEG | X-ray | 1.09 Å | C/D=516-580 |
| 6ZEH | X-ray | 1.3 Å | C/D=516-580 |
| 6ZEI | X-ray | 1.39 Å | C/D=516-580 |
| 6ZEJ | X-ray | 1.78 Å | A/D/F/I/L/O=526-580 |
| 6ZEE | X-ray | 1.9 Å | C/D/U/V/W/X=508-580 |
| 6ZEF | X-ray | 1.94 Å | C/D=516-580 |
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