Amyloid beta precursor protein binding family B member 2 (Apbb2) is a 760-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9DBR4.
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The mean pLDDT of this model is 60.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (PubMed:25757569, PubMed:27734846). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846). Activates transcription of APP (By similarity)
Interacts (via C-terminus) with APP (via C-terminus) (PubMed:18650440). Interacts with APLP2 (via cytoplasmic domain) (By similarity)
Endoplasmic reticulum, Golgi apparatus, Early endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1WGU | NMR | A=582-704 | |
| 2ROZ | NMR | B=582-704 | |
| 2YSZ | NMR | A=582-704 | |
| 2YT0 | NMR | A=564-567, A=582-704 | |
| 2YT1 | NMR | A=582-704 |
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