Bromodomain-containing protein 4 (Brd4) is a 1400-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9ESU6.
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The mean pLDDT of this model is 55.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 61% |
What pLDDT means and how to read it
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:10938129, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:10938129). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called…
Binds acetylated histone H4. Interacts with p53/TP53; the interaction is direct (By similarity). Interacts (via CTD region) with CDK9 and CCNT1, acting as an associated component of P-TEFb complex (PubMed:16109376). Interacts with RELA (when acetylated at 'Lys-310'). Interacts (via NET domain) with NSD3, CHD4, BICRA and ATAD5. The interaction with BICRA bridges BRD4 to the GBAF complex.…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3JVL | X-ray | 1.2 Å | A=349-464 |
| 3JVM | X-ray | 1.2 Å | A=349-464 |
| 3JVJ | X-ray | 1.55 Å | A=42-168 |
| 3MUL | X-ray | 1.65 Å | A=42-168 |
| 3MUK | X-ray | 1.75 Å | A=42-168 |
| 2DWW | X-ray | 1.8 Å | A=347-460 |
| 3JVK | X-ray | 1.8 Å | A=42-168 |
| 2JNS | NMR | A=601-683 |
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