Actin-related protein 6 (ACTR6) is a 396-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9GZN1.
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The mean pLDDT of this model is 94.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Required for formation and/or maintenance of proper nucleolar structure and function (PubMed:26164235). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity)
Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1 (PubMed:15647280, PubMed:20473270, PubMed:30337683). Interacts with CBX1, CBX3 and CBX5 (PubMed:16487625)
Cytoplasm, cytoskeleton, Nucleus, Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8X15 | EM | 3.2 Å | K=1-396 |
| 8X19 | EM | 3.2 Å | K=1-396 |
| 8X1C | EM | 3.2 Å | K=1-396 |
| 9CA7 | EM | 3.35 Å | C=1-396 |
| 9CA9 | EM | 3.56 Å | C=1-396 |
| 9CA8 | EM | 3.92 Å | C=1-396 |
| 9CAB | EM | 3.94 Å | C=1-396 |
| 6IGM | EM | 4.0 Å | G=1-396 |
| 9CAA | EM | 4.04 Å | C=1-396 |
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