9CA7: Helicase SRCAP
Cryo-EM structure of human SRCAP-nucleosome complex in the fully-engaged state (composite structure). Determined by electron microscopy at 3.35 Å resolution. Released 18 Jun 2025.
- Method
- Electron microscopy
- Resolution
- 3.35 Å
- Organisms
- Homo sapiens, Xenopus laevis, synthetic construct
- Chains
- 20
- Atoms
- 42,373
- Mol. weight
- 1041.11 kDa
- Ligands
- ADP, ZN, MG, AGS
- Released
- 18 Jun 2025
Explore 9CA7 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9CA7 contains 260 α-helices and 240 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 53 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 224-251 | 28 | |
| α-helix | 609-611 | 3 | |
| α-helix | 617-619 | 3 | |
| α-helix | 620-634 | 15 | |
| β-strand | 639-643 | 5 | 1 |
| α-helix | 644 | 1 | |
| α-helix | 649-659 | 11 | |
| α-helix | 660-664 | 5 | |
| α-helix | 669 | 1 | |
| β-strand | 670-674 | 5 | 1 |
| α-helix | 676-689 | 14 | |
| β-strand | 695-697 | 3 | 1 |
| α-helix | 702-709 | 8 | |
| β-strand | 720-724 | 5 | 1 |
| α-helix | 725-730 | 6 | |
| α-helix | 732-737 | 6 | |
| β-strand | 740-745 | 6 | 1 |
| α-helix | 748-751 | 4 | |
| α-helix | 757-763 | 7 | |
| β-strand | 767-773 | 7 | 1 |
| α-helix | 782-792 | 11 | |
| α-helix | 800-803 | 4 | |
| α-helix | 804-808 | 5 | |
| α-helix | 809-816 | 8 | |
| α-helix | 823-833 | 11 | |
| β-strand | 837-840 | 4 | 1 |
| α-helix | 842-845 | 4 | |
| β-strand | 852-859 | 8 | 2 |
| α-helix | 863-875 | 13 | |
| α-helix | 890-902 | 13 | |
| α-helix | 904-906 | 3 | |
| α-helix | 909-911 | 3 | |
| β-strand | 913 | 1 | 3 |
| β-strand | 916-917 | 2 | 4 |
| α-helix | 919-921 | 3 | |
| β-strand | 922-924 | 3 | 5 |
| α-helix | 929-931 | 3 | |
| α-helix | 937-939 | 3 | |
| α-helix | 943-946 | 4 | |
| α-helix | 949-951 | 3 | |
| α-helix | 957 | 1 | |
| α-helix | 958-963 | 6 | |
| α-helix | 964-967 | 4 | |
| β-strand | 968 | 1 | 6 |
| α-helix | 971-979 | 9 | |
| α-helix | 981-989 | 9 | |
| α-helix | 1887-1910 | 24 | |
| α-helix | 1920-1926 | 7 | |
| α-helix | 1937-1938 | 2 | |
| α-helix | 1946-1949 | 4 | |
| α-helix | 1953-1957 | 5 | |
| α-helix | 1962-1968 | 7 | |
| α-helix | 1970-1976 | 7 | |
| β-strand | 1983-1984 | 2 | 4 |
| α-helix | 1986-1988 | 3 | |
| β-strand | 1989-1991 | 3 | 5 |
| α-helix | 1999-2014 | 16 | |
| α-helix | 2016-2021 | 6 | |
| α-helix | 2022-2029 | 8 | |
| β-strand | 2031 | 1 | 3 |
| α-helix | 2032-2034 | 3 | |
| α-helix | 2036-2040 | 5 | |
| α-helix | 2043-2058 | 16 | |
| β-strand | 2062-2066 | 5 | 2 |
| α-helix | 2069-2082 | 14 | |
| β-strand | 2086-2089 | 4 | 2 |
| α-helix | 2095-2107 | 13 | |
| β-strand | 2113-2117 | 5 | 2 |
| β-strand | 2132-2135 | 4 | 2 |
| α-helix | 2142-2153 | 12 | |
| β-strand | 2161-2168 | 8 | 2 |
| α-helix | 2172-2190 | 19 | |
| α-helix | 2198-2202 | 5 | |
Chain B: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 169-201 | 33 | |
| β-strand | 211-220 | 10 | 7 |
| β-strand | 260-268 | 9 | 7 |
| α-helix | 271-277 | 7 | |
| α-helix | 281-288 | 8 | |
| β-strand | 291 | 1 | 8 |
| β-strand | 298 | 1 | 8 |
| α-helix | 299 | 1 | |
| β-strand | 301-302 | 2 | 9 |
| β-strand | 309-310 | 2 | 9 |
| α-helix | 313-330 | 18 | |
Chain C: 22 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-8 | 7 | 10 |
| β-strand | 12-17 | 6 | 10 |
| β-strand | 23-26 | 4 | 10 |
| β-strand | 29-31 | 3 | 11 |
| β-strand | 40-41 | 2 | 11 |
| α-helix | 42-46 | 5 | |
| β-strand | 55-57 | 3 | 11 |
| β-strand | 60-61 | 2 | 12 |
| β-strand | 64-65 | 2 | 12 |
| α-helix | 68-79 | 12 | |
| α-helix | 88-90 | 3 | |
| β-strand | 91-97 | 7 | 10 |
| α-helix | 103-111 | 9 | |
| α-helix | 112-116 | 5 | |
| β-strand | 121-126 | 6 | 10 |
| α-helix | 127-138 | 12 | |
| β-strand | 144-150 | 7 | 13 |
| β-strand | 155-161 | 7 | 13 |
| β-strand | 165 | 1 | 13 |
| β-strand | 171-173 | 3 | 13 |
| α-helix | 177-191 | 15 | |
| α-helix | 199-209 | 11 | |
| α-helix | 216-224 | 9 | |
| β-strand | 234-237 | 4 | 14 |
| β-strand | 248-249 | 2 | 14 |
| α-helix | 250-251 | 2 | |
| α-helix | 252-254 | 3 | |
| β-strand | 267-270 | 4 | 14 |
| α-helix | 273-282 | 10 | |
| α-helix | 284-286 | 3 | |
| α-helix | 294-304 | 11 | |
| α-helix | 310-314 | 5 | |
| β-strand | 317-320 | 4 | 13 |
| α-helix | 322-325 | 4 | |
| α-helix | 329-340 | 12 | |
| β-strand | 342 | 1 | 15 |
| β-strand | 349-350 | 2 | 13 |
| α-helix | 358-368 | 11 | |
| α-helix | 372-375 | 4 | |
| β-strand | 377-378 | 2 | 10 |
| α-helix | 379-381 | 3 | |
| α-helix | 382-386 | 5 | |
| α-helix | 387-393 | 7 | |
Chain D: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-34 | 14 | |
| α-helix | 84-91 | 8 | |
| β-strand | 105 | 1 | 13 |
| α-helix | 112-115 | 4 | |
| β-strand | 116 | 1 | 16 |
| β-strand | 123 | 1 | 16 |
| β-strand | 126-127 | 2 | 17 |
| β-strand | 134-135 | 2 | 17 |
| α-helix | 138-147 | 10 | |
Chain E: 23 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 18 |
| β-strand | 26 | 1 | 19 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 19 |
| α-helix | 33 | 1 | |
| β-strand | 36 | 1 | 20 |
| β-strand | 39 | 1 | 20 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 21 |
| β-strand | 65-69 | 5 | 22 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-96 | 4 | 22 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 121-141 | 21 | 23 |
| β-strand | 156-162 | 7 | 23 |
| β-strand | 167-172 | 6 | 23 |
| α-helix | 174-182 | 9 | |
| β-strand | 189-194 | 6 | 23 |
| β-strand | 199-206 | 8 | 23 |
| α-helix | 207-209 | 3 | |
| β-strand | 215 | 1 | 7 |
| β-strand | 220-221 | 2 | 23 |
| α-helix | 222-224 | 3 | |
| β-strand | 229-239 | 11 | 23 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-264 | 9 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-295 | 4 | 23 |
| β-strand | 298-301 | 4 | 22 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 24 |
| α-helix | 309-320 | 12 | |
| β-strand | 326-331 | 6 | 22 |
| β-strand | 333 | 1 | 25 |
| β-strand | 336-337 | 2 | 26 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 24 |
| β-strand | 345-346 | 2 | 26 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 22 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 27 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 27 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 28 |
| α-helix | 440-449 | 10 | |
| β-strand | 455 | 1 | 29 |
Chain F: 24 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 30 |
| β-strand | 33 | 1 | 31 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 31 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 32 |
| β-strand | 46-47 | 2 | 32 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 18 |
| β-strand | 72-77 | 6 | 28 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 28 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-124 | 10 | |
| β-strand | 127-150 | 24 | 7 |
| β-strand | 158-164 | 7 | 7 |
| β-strand | 169-174 | 6 | 7 |
| α-helix | 175 | 1 | |
| α-helix | 176-185 | 10 | |
| β-strand | 191-196 | 6 | 7 |
| β-strand | 202-207 | 6 | 7 |
| α-helix | 210 | 1 | |
| β-strand | 211 | 1 | 7 |
| α-helix | 212 | 1 | |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 7 |
| α-helix | 244-252 | 9 | |
| α-helix | 256-262 | 7 | |
| α-helix | 270-285 | 16 | |
| β-strand | 289-293 | 5 | 7 |
| β-strand | 295-299 | 5 | 28 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 33 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 28 |
| β-strand | 330 | 1 | 29 |
| β-strand | 332-334 | 3 | 34 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 33 |
| β-strand | 341-343 | 3 | 34 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 28 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-377 | 14 | |
| β-strand | 382 | 1 | 35 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 35 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 36 |
| α-helix | 436-445 | 10 | |
Chain G: 24 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 37 |
| β-strand | 26 | 1 | 38 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 38 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 39 |
| β-strand | 39-40 | 2 | 39 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 30 |
| β-strand | 65-69 | 5 | 36 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 36 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-119 | 12 | |
| β-strand | 120-142 | 23 | 7 |
| β-strand | 152-163 | 12 | 7 |
| β-strand | 166-172 | 7 | 7 |
| α-helix | 176-182 | 7 | |
| β-strand | 189-194 | 6 | 7 |
| β-strand | 199-206 | 8 | 7 |
| α-helix | 207-209 | 3 | |
| β-strand | 214 | 1 | 40 |
| β-strand | 220-221 | 2 | 7 |
| α-helix | 222-225 | 4 | |
| β-strand | 229-239 | 11 | 7 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-263 | 8 | |
| α-helix | 265-266 | 2 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 7 |
| β-strand | 298-302 | 5 | 36 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 41 |
| α-helix | 309-319 | 11 | |
| β-strand | 326-331 | 6 | 36 |
| β-strand | 336-337 | 2 | 42 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 41 |
| β-strand | 345-346 | 2 | 42 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 36 |
| α-helix | 364-367 | 4 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 43 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-407 | 5 | |
| α-helix | 410-420 | 11 | |
| β-strand | 425 | 1 | 43 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 44 |
| α-helix | 440-449 | 10 | |
| β-strand | 455 | 1 | 45 |
Chain H: 23 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 46 |
| β-strand | 33 | 1 | 47 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 47 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 48 |
| β-strand | 46-47 | 2 | 48 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 37 |
| β-strand | 72-77 | 6 | 44 |
| α-helix | 83-93 | 11 | |
| β-strand | 100-104 | 5 | 44 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-148 | 22 | 40 |
| β-strand | 158-164 | 7 | 40 |
| β-strand | 169-174 | 6 | 40 |
| α-helix | 176-184 | 9 | |
| β-strand | 191-196 | 6 | 40 |
| β-strand | 202-207 | 6 | 40 |
| α-helix | 211-213 | 3 | |
| β-strand | 217 | 1 | 15 |
| β-strand | 224 | 1 | 40 |
| β-strand | 225 | 1 | 6 |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 40 |
| α-helix | 244-250 | 7 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 270-286 | 17 | |
| β-strand | 289-293 | 5 | 40 |
| β-strand | 295-299 | 5 | 44 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 49 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 44 |
| β-strand | 330 | 1 | 45 |
| β-strand | 333-334 | 2 | 50 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 49 |
| β-strand | 341-342 | 2 | 50 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 44 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 51 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 51 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 52 |
| α-helix | 436-445 | 10 | |
| β-strand | 451 | 1 | 53 |
9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Helicase SRCAP | A | protein | 3230 | Homo sapiens | Q6ZRS2 |
| Vacuolar protein sorting-associated protein 72 homolog | B | protein | 364 | Homo sapiens | Q15906 (AlphaFold model) |
| Actin-related protein 6 | C | protein | 396 | Homo sapiens | Q9GZN1 (AlphaFold model) |
| Zinc finger HIT domain-containing protein 1 | D | protein | 154 | Homo sapiens | O43257 (AlphaFold model) |
| RuvB-like 1 | E, G, I | protein | 456 | Homo sapiens | Q9Y265 |
| RuvB-like 2 | F, H, J | protein | 463 | Homo sapiens | Q9Y230 |
| Histone H2A type 1 | Q, S | protein | 128 | Xenopus laevis | P06897 |
| Histone H2B 1.1 | R, T | protein | 125 | Xenopus laevis | P02281 |
| Histone H3.2 | U, W | protein | 135 | Xenopus laevis | P84233 |
| Histone H4 | V, X | protein | 102 | Xenopus laevis | P62799 |
| DNA (285-mer) | Y | DNA | 285 | synthetic construct | |
| DNA (285-mer) | Z | DNA | 285 | synthetic construct | |
Sequence of entity 1 (A), FASTA
>9CA7_1 Helicase SRCAP (chains A)
MQSSPSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGP
PGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWS
LKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKE
ERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDE
ETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSD
TRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAE
EQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPE
GPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQA
DEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPGPTTLGPKKEITDIAAAAESLQPKGYT
LATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHL
ACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHV
CITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQN
SLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR
VKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKV
CNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEA
DTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLG
PVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSG
SLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFP
PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVAN
AGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALI
QAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDG
LTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHS
PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLP
ISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP
SASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFP
SAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAP
VLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQT
LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPL
GPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGP
AAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSP
PSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGT
EVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVM
PPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQY
DCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQA
LMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRD
VHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSS
SVPSAPEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAG
EGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVE
AARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLR
GARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPV
PVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCL
VTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLV
PPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGE
ELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAA
PSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEE
KELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTP
PQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEA
PSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRG
RPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTIST
SPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGS
RPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRST
RLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEE
EEGDGTPRRRPGPRRLVGTTNQGDQRILRSSAPPSLAGPAVSHRGRKAKT
Sequence of entity 2 (B), FASTA
>9CA7_2 Vacuolar protein sorting-associated protein 72 homolog (chains B)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK
Sequence of entity 3 (C), FASTA
>9CA7_3 Actin-related protein 6 (chains C)
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPF
QKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQ
AVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLL
TNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPD
FSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAW
EGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
Sequence of entity 4 (D), FASTA
>9CA7_4 Zinc finger HIT domain-containing protein 1 (chains D)
MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDD
DADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVC
GFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV
Sequence of entity 5 (E, G, I), FASTA
>9CA7_5 RuvB-like 1 (chains E, G, I)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Sequence of entity 6 (F, H, J), FASTA
>9CA7_6 RuvB-like 2 (chains F, H, J)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Sequence of entity 7 (Q, S), FASTA
>9CA7_7 Histone H2A type 1 (chains Q, S)
SGRGKQGGKTRAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNIQSVLLPKKT
ESSKSKSK
Sequence of entity 8 (R, T), FASTA
>9CA7_8 Histone H2B 1.1 (chains R, T)
PEPAKSAPAPKKGSKKAVTKTQKKDGKKRRKTRKESYAIYVYKVLKQVHPDTGISSKAMS
IMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTK
YTSAK
Sequence of entity 9 (U, W), FASTA
>9CA7_9 Histone H3.2 (chains U, W)
ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTEL
LIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLCAIHAKRVTIM
PKDIQLARRIRGERA
Sequence of entity 10 (V, X), FASTA
>9CA7_10 Histone H4 (chains V, X)
SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Sequence of entity 11 (Y), FASTA
>9CA7_11 DNA (285-MER) (chains Y)
ATCGAAGGGCGCCTATATAAGGGGGTGGGGGCGCGTTCGTCCTCCCTCTCCTCGCGGCGC
GAGTTTCAGGCAGCGCTGCGTCCTGCTGCGCACGTGGGAAGCCCTGCTGGAGAATCCCGG
TGCGCAGGCCGCTCAATTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCAGCTACGCGC
TGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAGGCAGCTGTCAGAT
ATGTACATCCTGTGATCCCCGGGTACCGAGCTCGAATTCACTGGC
Sequence of entity 12 (Z), FASTA
>9CA7_12 DNA (285-MER) (chains Z)
GCCAGTGAATTCGAGCTCGGTACCCGGGGATCACAGGATGTACATATCTGACAGCTGCCT
GGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTAGCTGCGTT
TAAGCGGTGCTAGAGCTGTCTACGACCAATTGAGCGGCCTGCGCACCGGGATTCTCCAGC
AGGGCTTCCCACGTGCGCAGCAGGACGCAGCGCTGCCTGAAACTCGCGCCGCGAGGAGAG
GGAGGACGAACGCGCCCCCACCCCCTTATATAGGCGCCCTTCGAT
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 6 |
| ZN | Zinc ion | Zn | 2 |
| MG | Magnesium ion | Mg | 5 |
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 2 |
Primary citation
Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme. Park, G., Wu, C., Louder, R.K. Sci Adv (2026) 12:eaei7728-eaei7728. DOI 10.1126/sciadv.aei7728 · PubMed
Other PDB entries of the same protein (UniProt Q6ZRS2), best resolution first:
- 9UBD 2.53 Å, The Structural Basis of the Recognition of the Histone Variant H2A.Z by the SRCAP…
- 8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
- 8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
- 8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state
- 9NFX 3.3 Å, Human SRCAP-CFDP1-hexasome complex in the evicted state of the H2A.Z histone exchange…
- 9NFY 3.4 Å, Human SRCAP-CFDP1-prenucleosome complex in the pre-inserted state of the H2A.Z histone…
- 9CA9 3.56 Å, Cryo-EM structure of the human SRCAP complex in the unbound state (composite structure)
- 9NFV 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the poised state of the H2A.Z histone exchange…
- 9NFW 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the activated state of the H2A.Z histone…
- 9NFZ 3.8 Å, Human SRCAP-nucleosome complex in the fully inserted state of the H2A.Z histone exchange…
- 9PGC 3.8 Å, Trident submodule from human SRCAP-nucleosome complex in the fully-engaged state…
- 9NG0 3.9 Å, Human SRCAP-nucleosome complex in the pre-dissociation state of the H2A.Z histone…
Browse structure collections
About this viewer
MolViewer shows 9CA7 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.