9CA9: Human SRCAP complex in the unbound state
Cryo-EM structure of the human SRCAP complex in the unbound state (composite structure). Determined by electron microscopy at 3.56 Å resolution. Released 18 Jun 2025.
- Method
- Electron microscopy
- Resolution
- 3.56 Å
- Organism
- Homo sapiens
- Chains
- 10
- Atoms
- 28,589
- Mol. weight
- 755.87 kDa
- Ligands
- ZN, MG, AGS, ADP
- Released
- 18 Jun 2025
Explore 9CA9 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9CA9 contains 196 α-helices and 209 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 31 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 852-859 | 8 | 1 |
| α-helix | 863-876 | 14 | |
| α-helix | 890-902 | 13 | |
| α-helix | 904-906 | 3 | |
| α-helix | 909-911 | 3 | |
| β-strand | 913 | 1 | 2 |
| β-strand | 916-917 | 2 | 3 |
| α-helix | 919-921 | 3 | |
| β-strand | 922-925 | 4 | 4 |
| α-helix | 929-931 | 3 | |
| α-helix | 937-939 | 3 | |
| α-helix | 943-946 | 4 | |
| α-helix | 949-951 | 3 | |
| α-helix | 957-958 | 2 | |
| α-helix | 959-963 | 5 | |
| α-helix | 964-967 | 4 | |
| β-strand | 968 | 1 | 5 |
| α-helix | 971-979 | 9 | |
| α-helix | 981-989 | 9 | |
| α-helix | 1887-1910 | 24 | |
| α-helix | 1920-1926 | 7 | |
| α-helix | 1937-1938 | 2 | |
| α-helix | 1946-1949 | 4 | |
| α-helix | 1953-1957 | 5 | |
| α-helix | 1962-1968 | 7 | |
| α-helix | 1970-1976 | 7 | |
| β-strand | 1983-1984 | 2 | 3 |
| α-helix | 1986-1988 | 3 | |
| β-strand | 1989-1992 | 4 | 4 |
| α-helix | 1999-2014 | 16 | |
| α-helix | 2015-2021 | 7 | |
| α-helix | 2022-2029 | 8 | |
| β-strand | 2031 | 1 | 2 |
| α-helix | 2036-2040 | 5 | |
| α-helix | 2043-2058 | 16 | |
| β-strand | 2062-2066 | 5 | 1 |
| α-helix | 2069-2082 | 14 | |
| β-strand | 2086-2089 | 4 | 1 |
| α-helix | 2095-2107 | 13 | |
| β-strand | 2113-2117 | 5 | 1 |
| β-strand | 2132-2135 | 4 | 1 |
| α-helix | 2142-2153 | 12 | |
| β-strand | 2161-2168 | 8 | 1 |
| α-helix | 2172-2179 | 8 | |
Chain B: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 211-220 | 10 | 6 |
| β-strand | 260-268 | 9 | 6 |
| α-helix | 271-277 | 7 | |
| α-helix | 281-288 | 8 | |
| β-strand | 291 | 1 | 7 |
| β-strand | 298 | 1 | 7 |
| α-helix | 299 | 1 | |
| β-strand | 301-303 | 3 | 8 |
| β-strand | 308-310 | 3 | 8 |
| α-helix | 313-330 | 18 | |
Chain C: 21 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-8 | 7 | 9 |
| β-strand | 12-17 | 6 | 9 |
| β-strand | 23-26 | 4 | 9 |
| β-strand | 29-31 | 3 | 10 |
| β-strand | 39-41 | 3 | 10 |
| α-helix | 42-46 | 5 | |
| β-strand | 55-57 | 3 | 10 |
| β-strand | 60-61 | 2 | 11 |
| β-strand | 64-65 | 2 | 11 |
| α-helix | 68-79 | 12 | |
| α-helix | 88-90 | 3 | |
| β-strand | 91-97 | 7 | 9 |
| α-helix | 103-111 | 9 | |
| α-helix | 112-116 | 5 | |
| β-strand | 121-126 | 6 | 9 |
| α-helix | 127-138 | 12 | |
| β-strand | 145-150 | 6 | 12 |
| β-strand | 155-160 | 6 | 12 |
| β-strand | 165 | 1 | 12 |
| α-helix | 167-169 | 3 | |
| β-strand | 171-173 | 3 | 12 |
| α-helix | 177-191 | 15 | |
| α-helix | 199-209 | 11 | |
| α-helix | 216-224 | 9 | |
| β-strand | 234-237 | 4 | 13 |
| β-strand | 248-249 | 2 | 13 |
| α-helix | 250-251 | 2 | |
| α-helix | 252-254 | 3 | |
| β-strand | 267-270 | 4 | 13 |
| α-helix | 273-282 | 10 | |
| α-helix | 284-286 | 3 | |
| α-helix | 294-304 | 11 | |
| α-helix | 310-314 | 5 | |
| β-strand | 317-320 | 4 | 12 |
| α-helix | 322-325 | 4 | |
| α-helix | 329-340 | 12 | |
| β-strand | 342 | 1 | 14 |
| β-strand | 349-350 | 2 | 12 |
| α-helix | 358-368 | 11 | |
| α-helix | 372-375 | 4 | |
| β-strand | 377-378 | 2 | 9 |
| α-helix | 379-393 | 15 | |
Chain D: 5 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-34 | 14 | |
| α-helix | 84-91 | 8 | |
| α-helix | 102-104 | 3 | |
| β-strand | 105 | 1 | 12 |
| α-helix | 112-115 | 4 | |
| β-strand | 116 | 1 | 15 |
| β-strand | 123 | 1 | 15 |
| β-strand | 126-127 | 2 | 16 |
| β-strand | 134-135 | 2 | 16 |
| α-helix | 138-147 | 10 | |
Chain E: 23 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 17 |
| β-strand | 26 | 1 | 18 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 18 |
| α-helix | 33 | 1 | |
| β-strand | 36 | 1 | 19 |
| β-strand | 39 | 1 | 19 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 20 |
| β-strand | 65-69 | 5 | 21 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-96 | 4 | 21 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 121-141 | 21 | 22 |
| β-strand | 156-162 | 7 | 22 |
| β-strand | 167-172 | 6 | 22 |
| α-helix | 174-182 | 9 | |
| β-strand | 189-194 | 6 | 22 |
| β-strand | 199-206 | 8 | 22 |
| α-helix | 207-209 | 3 | |
| β-strand | 215 | 1 | 6 |
| β-strand | 220-221 | 2 | 22 |
| α-helix | 222-224 | 3 | |
| β-strand | 229-239 | 11 | 22 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-264 | 9 | |
| α-helix | 273-288 | 16 | |
| β-strand | 292-295 | 4 | 22 |
| β-strand | 298-301 | 4 | 21 |
| α-helix | 304-306 | 3 | |
| α-helix | 309-320 | 12 | |
| β-strand | 326-331 | 6 | 21 |
| β-strand | 333 | 1 | 23 |
| β-strand | 336-337 | 2 | 24 |
| α-helix | 338 | 1 | |
| β-strand | 345-346 | 2 | 24 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 21 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 25 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 25 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 26 |
| α-helix | 440-449 | 10 | |
| β-strand | 455 | 1 | 27 |
Chain F: 21 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 28 |
| β-strand | 33 | 1 | 29 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 29 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 30 |
| β-strand | 46-47 | 2 | 30 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 17 |
| β-strand | 72-77 | 6 | 26 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 26 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-124 | 10 | |
| β-strand | 127-150 | 24 | 6 |
| β-strand | 158-164 | 7 | 6 |
| β-strand | 169-174 | 6 | 6 |
| α-helix | 176-185 | 10 | |
| β-strand | 191-196 | 6 | 6 |
| β-strand | 202-207 | 6 | 6 |
| β-strand | 211 | 1 | 6 |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 6 |
| α-helix | 244-252 | 9 | |
| α-helix | 256-262 | 7 | |
| α-helix | 270-286 | 17 | |
| β-strand | 289-293 | 5 | 6 |
| β-strand | 295-299 | 5 | 26 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 31 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 26 |
| β-strand | 330 | 1 | 27 |
| β-strand | 332-334 | 3 | 32 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 31 |
| β-strand | 341-343 | 3 | 32 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 26 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-377 | 14 | |
| β-strand | 382 | 1 | 33 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 33 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 34 |
| α-helix | 436-445 | 10 | |
Chain G: 24 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 35 |
| β-strand | 26 | 1 | 36 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 36 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 37 |
| β-strand | 39-40 | 2 | 37 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 28 |
| β-strand | 65-69 | 5 | 34 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 34 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-119 | 12 | |
| β-strand | 120-142 | 23 | 6 |
| β-strand | 152-163 | 12 | 6 |
| β-strand | 166-172 | 7 | 6 |
| α-helix | 176-182 | 7 | |
| β-strand | 189-194 | 6 | 6 |
| β-strand | 199-206 | 8 | 6 |
| α-helix | 207-209 | 3 | |
| β-strand | 214 | 1 | 38 |
| β-strand | 220-221 | 2 | 6 |
| α-helix | 222-225 | 4 | |
| β-strand | 229-239 | 11 | 6 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-263 | 8 | |
| α-helix | 265-266 | 2 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 6 |
| β-strand | 298-302 | 5 | 34 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 39 |
| α-helix | 309-320 | 12 | |
| β-strand | 326-331 | 6 | 34 |
| β-strand | 336-337 | 2 | 40 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 39 |
| β-strand | 345-346 | 2 | 40 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 34 |
| α-helix | 364-367 | 4 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 41 |
| α-helix | 388-399 | 12 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-420 | 11 | |
| β-strand | 425 | 1 | 41 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 42 |
| α-helix | 440-449 | 10 | |
| β-strand | 455 | 1 | 43 |
Chain H: 23 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 44 |
| β-strand | 33 | 1 | 45 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 45 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 46 |
| β-strand | 46-47 | 2 | 46 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 35 |
| β-strand | 72-77 | 6 | 42 |
| α-helix | 83-93 | 11 | |
| β-strand | 100-104 | 5 | 42 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-148 | 22 | 38 |
| β-strand | 158-164 | 7 | 38 |
| β-strand | 169-174 | 6 | 38 |
| α-helix | 176-184 | 9 | |
| β-strand | 191-196 | 6 | 38 |
| β-strand | 202-207 | 6 | 38 |
| α-helix | 211-213 | 3 | |
| β-strand | 217 | 1 | 14 |
| β-strand | 224 | 1 | 38 |
| β-strand | 225 | 1 | 5 |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 38 |
| α-helix | 244-250 | 7 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 270-286 | 17 | |
| β-strand | 289-293 | 5 | 38 |
| β-strand | 295-299 | 5 | 42 |
| α-helix | 301-303 | 3 | |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 42 |
| β-strand | 330 | 1 | 43 |
| β-strand | 333-334 | 2 | 47 |
| α-helix | 335 | 1 | |
| β-strand | 341-342 | 2 | 47 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 42 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 48 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 48 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 49 |
| α-helix | 436-445 | 10 | |
| β-strand | 451 | 1 | 50 |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Helicase SRCAP | A | protein | 3230 | Homo sapiens | Q6ZRS2 |
| Vacuolar protein sorting-associated protein 72 homolog | B | protein | 364 | Homo sapiens | Q15906 (AlphaFold model) |
| Actin-related protein 6 | C | protein | 396 | Homo sapiens | Q9GZN1 (AlphaFold model) |
| Zinc finger HIT domain-containing protein 1 | D | protein | 154 | Homo sapiens | O43257 (AlphaFold model) |
| RuvB-like 1 | E, G, I | protein | 456 | Homo sapiens | Q9Y265 |
| RuvB-like 2 | F, H, J | protein | 463 | Homo sapiens | Q9Y230 |
Sequence of entity 1 (A), FASTA
>9CA9_1 Helicase SRCAP (chains A)
MQSSPSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGP
PGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWS
LKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKE
ERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDE
ETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSD
TRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAE
EQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPE
GPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQA
DEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPGPTTLGPKKEITDIAAAAESLQPKGYT
LATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHL
ACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHV
CITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQN
SLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR
VKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKV
CNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEA
DTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLG
PVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSG
SLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFP
PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVAN
AGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALI
QAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDG
LTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHS
PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLP
ISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP
SASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFP
SAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAP
VLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQT
LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPL
GPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGP
AAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSP
PSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGT
EVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVM
PPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQY
DCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQA
LMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRD
VHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSS
SVPSAPEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAG
EGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVE
AARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLR
GARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPV
PVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCL
VTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLV
PPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGE
ELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAA
PSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEE
KELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTP
PQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEA
PSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRG
RPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTIST
SPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGS
RPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRST
RLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEE
EEGDGTPRRRPGPRRLVGTTNQGDQRILRSSAPPSLAGPAVSHRGRKAKT
Sequence of entity 2 (B), FASTA
>9CA9_2 Vacuolar protein sorting-associated protein 72 homolog (chains B)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK
Sequence of entity 3 (C), FASTA
>9CA9_3 Actin-related protein 6 (chains C)
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPF
QKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQ
AVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLL
TNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPD
FSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAW
EGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
Sequence of entity 4 (D), FASTA
>9CA9_4 Zinc finger HIT domain-containing protein 1 (chains D)
MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDD
DADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVC
GFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV
Sequence of entity 5 (E, G, I), FASTA
>9CA9_5 RuvB-like 1 (chains E, G, I)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Sequence of entity 6 (F, H, J), FASTA
>9CA9_6 RuvB-like 2 (chains F, H, J)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 2 |
| MG | Magnesium ion | Mg | 4 |
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 6 |
Primary citation
Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme. Park, G., Wu, C., Louder, R.K. Sci Adv (2026) 12:eaei7728-eaei7728. DOI 10.1126/sciadv.aei7728 · PubMed
Other PDB entries of the same protein (UniProt Q6ZRS2), best resolution first:
- 9UBD 2.53 Å, The Structural Basis of the Recognition of the Histone Variant H2A.Z by the SRCAP…
- 8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
- 8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
- 8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state
- 9NFX 3.3 Å, Human SRCAP-CFDP1-hexasome complex in the evicted state of the H2A.Z histone exchange…
- 9CA7 3.35 Å, Cryo-EM structure of human SRCAP-nucleosome complex in the fully-engaged state…
- 9NFY 3.4 Å, Human SRCAP-CFDP1-prenucleosome complex in the pre-inserted state of the H2A.Z histone…
- 9NFV 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the poised state of the H2A.Z histone exchange…
- 9NFW 3.8 Å, Human SRCAP-CFDP1-nucleosome complex in the activated state of the H2A.Z histone…
- 9NFZ 3.8 Å, Human SRCAP-nucleosome complex in the fully inserted state of the H2A.Z histone exchange…
- 9PGC 3.8 Å, Trident submodule from human SRCAP-nucleosome complex in the fully-engaged state…
- 9NG0 3.9 Å, Human SRCAP-nucleosome complex in the pre-dissociation state of the H2A.Z histone…
Browse structure collections
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