NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) is a 922-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H0M0.
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The mean pLDDT of this model is 75.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment…
Interacts with the Crumbs complex components PALS1 and PATJ; interaction with the Crumbs complex is enhanced by WWP1's interaction with AMOTL2 and facilitates WWP1 localization to the plasma membrane (PubMed:34404733). Interaction with the Crumbs complex promotes WWP1 monoubiquitination of AMOTL2, which activates the Hippo signaling pathway (PubMed:34404733). Binds KLF2 and HIVEP3 (By…
Cytoplasm, Cell membrane, Nucleus, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5HPS | X-ray | 2.05 Å | A=537-917 |
| 1ND7 | X-ray | 2.1 Å | A=546-917 |
| 6J1X | X-ray | 2.3 Å | B=379-922 |
| 8EI4 | X-ray | 2.43 Å | A=546-917 |
| 6J1Y | X-ray | 2.55 Å | A/B=410-922 |
| 5HPT | X-ray | 2.84 Å | A/D/G=537-917 |
| 9EQK | X-ray | 3.0 Å | A/B=379-922 |
| 2OP7 | NMR | A=494-532 |
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