9EQK: NEDD4-like E3 ubiquitin-protein ligase WWP1

WWP1 WW2-2,3-linker-WW3-WW4-HECT (WWP1-2L34H) with ordered WW2 domain. Determined by X-ray diffraction at 3.0 Å resolution. Released 15 May 2024.

Method
X-ray diffraction
Resolution
3.0 Å
Organism
Homo sapiens
Chains
2
Atoms
8,678
Mol. weight
130.14 kDa
Released
15 May 2024

Explore 9EQK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EQK contains 59 α-helices and 46 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 23 β-strands

ElementResiduesLengthSheet
α-helix9-124
β-strand15-1951
β-strand25-2951
β-strand3611
α-helix42-5716
α-helix61-677
α-helix75-773
α-helix85-873
β-strand90-9452
β-strand99-10352
β-strand108-11032
α-helix125-1273
β-strand130-13343
β-strand141-14443
β-strand14913
α-helix175-18713
β-strand194-19964
α-helix206-2094
α-helix217-2215
β-strand223-22864
α-helix236-25015
α-helix254-2563
β-strand259-26355
β-strand267-27155
α-helix273-2775
α-helix281-29717
α-helix308-3147
α-helix321-3277
α-helix329-33911
β-strand35116
β-strand353-35537
β-strand364-36637
α-helix371-3733
β-strand37516
α-helix381-39414
α-helix398-40912
α-helix414-4174
α-helix422-4298
α-helix433-4353
α-helix437-4426
β-strand445-44738
α-helix454-46512
α-helix468-47811
α-helix483-4853
α-helix489-4913
β-strand493-49539
β-strand497-49829
β-strand502-50438
β-strand514-51638
α-helix517-5193
β-strand521-52338
α-helix530-54213
Chain B: 30 helices, 23 β-strands
ElementResiduesLengthSheet
α-helix10-123
β-strand15-19510
β-strand25-29510
β-strand35-36210
α-helix42-5918
α-helix62-654
α-helix67-726
α-helix86-872
β-strand90-94511
β-strand100-104511
β-strand110-111211
β-strand130-134512
β-strand140-144512
β-strand149-151312
α-helix175-18713
β-strand194-199613
α-helix204-2096
α-helix217-2215
β-strand223-228613
α-helix237-25014
α-helix254-2563
β-strand259-261314
β-strand269-271314
α-helix273-2775
α-helix281-29717
α-helix308-3147
α-helix317-3193
α-helix321-3255
α-helix329-34012
α-helix343-3453
β-strand351115
β-strand353-357516
β-strand362-366516
α-helix371-3733
β-strand375115
α-helix381-39212
α-helix398-41114
α-helix414-4174
α-helix422-4309
α-helix433-4353
α-helix437-4426
β-strand444-447417
α-helix454-46411
α-helix468-47912
α-helix489-4913
β-strand493118
β-strand498118
β-strand501-505517
α-helix512-5132
β-strand514-516317
α-helix517-5193
β-strand521-524417
α-helix530-54011

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
NEDD4-like E3 ubiquitin-protein ligase WWP1A, Bprotein550Homo sapiensQ9H0M0 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>9EQK_1 NEDD4-like E3 ubiquitin-protein ligase WWP1 (chains A, B)
GPGSEFRPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQG
AMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGL
QNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLA
HFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLA
REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGK
FIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILG
KVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYF
DEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTG
TCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA
IEETEGFGQE

Primary citation

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases. Dudey, A.P., Rigby, J.M., Hughes, G.R. et al. J Enzyme Inhib Med Chem (2024) 39:2394895-2394895. DOI 10.1080/14756366.2024.2394895 · PubMed

Other PDB entries of the same protein (UniProt Q9H0M0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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