BCL11 transcription factor A (BCL11A) is a 835-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H165.
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The mean pLDDT of this model is 52.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 66% |
What pLDDT means and how to read it
Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential…
Homotetrameric; self-associates via C2HC-type zinc finger domain (PubMed:39607926). Interacts with MTA2, a component of the nucleosome remodeling and deacetylase (NuRD) repressor complex (PubMed:39607926). Interacts (via its C2H2-type zinc finger domains 4, 5 and 6) with promoter region of gamma-globulin (PubMed:39423807). Interacts with NR2F1, PIAS3, NR2F2 and NR2F6 (By similarity). Isoform 1,…
Cytoplasm, Nucleus, Chromosome, Nucleus matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6U9Q | X-ray | 1.83 Å | A=730-835 |
| 9YLM | X-ray | 1.91 Å | A=730-835 |
| 9YLO | X-ray | 1.97 Å | A=373-433 |
| 9YLP | X-ray | 2.04 Å | A=373-433 |
| 9E6R | X-ray | 2.09 Å | A/D/Y=730-835 |
| 9YLN | X-ray | 2.15 Å | A=730-835 |
| 8DTN | X-ray | 2.2 Å | B/D/F/H=797-826 |
| 9E6S | X-ray | 2.2 Å | A/D=730-835 |
| 9YLL | X-ray | 2.38 Å | A=730-835 |
| 5VTB | X-ray | 2.4 Å | B=2-16 |
| 8DTU | X-ray | 2.45 Å | C=799-826 |
| 6KI6 | X-ray | 2.5 Å | A/B=731-835 |
| 9B4P | X-ray | 2.56 Å | A/B/C/D/E/F/G/H/I/J=45-71 |
| 8TLO | X-ray | 2.76 Å | A=730-835 |
| 9E6T | X-ray | 2.78 Å | A/B=730-835 |
| 8THO | NMR | A=737-835 | |
| 9BV0 | NMR | A=46-72 |
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