Thioredoxin-interacting protein (TXNIP) is a 391-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H3M7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of…
Homodimer; disulfide-linked (PubMed:23519408). Interacts with TXN/thioredoxin through its redox-active site (PubMed:17603038). Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (PubMed:12821938). Interacts with DDIT4 (PubMed:21460850)
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CQ2 | X-ray | 1.4 Å | B/C=327-338 |
| 4GEI | X-ray | 1.5 Å | A=2-149 |
| 5DZD | X-ray | 1.57 Å | C/D=327-338 |
| 4GFX | X-ray | 1.6 Å | A=4-154 |
| 5DWS | X-ray | 1.65 Å | B/D/F/H=327-338 |
| 5DF6 | X-ray | 1.78 Å | B/C=371-382 |
| 4ROJ | X-ray | 1.95 Å | D/E/F=327-338 |
| 4LL1 | X-ray | 2.0 Å | A/C=3-317 |
| 4ROF | X-ray | 2.03 Å | C/D=327-338 |
| 4LL4 | X-ray | 2.7 Å | A/C=3-317 |
| 4GEJ | X-ray | 2.9 Å | A/B/C/D/E/F/G/H/I/J=2-149 |
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