MOB kinase activator 1A (MOB1A) is a 216-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H8S9.
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The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.…
Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4J1V | X-ray | 1.95 Å | A/C=33-216 |
| 1PI1 | X-ray | 2.0 Å | A=33-216 |
| 4JIZ | X-ray | 2.1 Å | A=40-211 |
| 5XQZ | X-ray | 2.1 Å | A/B=33-216 |
| 5BRK | X-ray | 2.3 Å | A=1-216 |
| 5TWG | X-ray | 2.3 Å | A=1-216 |
| 5TWH | X-ray | 2.5 Å | A=1-216 |
| 6MCP | X-ray | 2.5 Å | B/D=33-216 |
| 6MCQ | X-ray | 2.57 Å | B/D=33-216 |
| 5BRM | X-ray | 2.65 Å | A/B/C/D/E/F=41-216 |
| 5TWF | X-ray | 3.14 Å | A/B=1-216 |
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