5TWG: Human MOB1A

human MOB1A bound to human MST1 phosphorylated T353 peptide. Determined by X-ray diffraction at 2.3 Å resolution. Released 12 Apr 2017.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,596
Mol. weight: 26.79 kDa
Ligands: ZN
Released: 12 Apr 2017

Explore 5TWG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5TWG contains 14 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	24-35	12
α-helix	36-38	3
α-helix	41-44	4
α-helix	47-48	2
α-helix	53-74	22
α-helix	76-78	3
β-strand	87-89	3	1
β-strand	93-95	3	1
β-strand	97	1	2
β-strand	107	1	2
α-helix	111-126	16
α-helix	139-141	3
α-helix	144-164	21
α-helix	167-172	6
α-helix	176-193	18
α-helix	198-201	4
α-helix	202-204	3
α-helix	205-210	6

Chain E: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	6-7	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MOB kinase activator 1A	A	protein	216	Homo sapiens	Q9H8S9 (AlphaFold model)
T353 peptide	E	protein	15	Homo sapiens	Q13043 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5TWG_1 MOB kinase activator 1A (chains A)
MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN
TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT
WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN
TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR

Sequence of entity 2 (E), FASTA

>5TWG_2 T353 peptide (chains E)
VASTMTDGANTMIEP

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway. Couzens, A.L., Xiong, S., Knight, J.D.R. et al. Mol Cell Proteomics (2017) 16:1098-1110. DOI 10.1074/mcp.M116.065490 · PubMed

Other PDB entries of the same protein (UniProt Q9H8S9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4J1V 1.95 Å, Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor…
1PI1 2.0 Å, Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle…
4JIZ 2.1 Å, Human Mob1-phosphopeptide complex
5XQZ 2.1 Å, Structure of the MOB1-NDR2 complex
5BRK 2.3 Å, pMob1-Lats1 complex
5TWH 2.5 Å, human MOB1A bound to MST1 phosphorylated T367 peptide
6MCP 2.5 Å, L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A
6MCQ 2.57 Å, L. pneumophila effector kinase LegK7 in complex with human MOB1A
5BRM 2.65 Å, Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in…
5TWF 3.14 Å, Regulation of protein interactions by MOB1 phosphorylation

Browse structure collections

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