Nectin-3 (Nectin3) is a 549-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9JLB9.
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The mean pLDDT of this model is 73.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:10744716, PubMed:11827984, PubMed:12121624, PubMed:12558799, PubMed:15328010, PubMed:16128743, PubMed:21798896). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16128743). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16128743). Involved in axon guidance by promoting contacts between the…
Cis- and trans-homodimer (PubMed:10744716, PubMed:11827984). Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4 (PubMed:12826663, PubMed:15741237, PubMed:16128743, PubMed:21798896). Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites…
Cell membrane, Postsynaptic cell membrane, Cell junction, adherens junction
Compare the prediction with experimentally determined structures of the same protein:
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