Neisserial heparin binding antigen (nhba) is a 427-residue protein from Neisseria meningitidis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9JPP1.
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The mean pLDDT of this model is 57.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
A major human immunogenic protein detected in patients recovering from meningitidis, where it induces bactericidal antibodies (By similarity) (PubMed:30133484). Binds human cells, heparin and heparan sulfate proteoglycan in vitro via the Arg-rich motif. Heparin-binding to this protein protects bacteria against killing by bactericidal antibodies (serum killing). The bacteria binds a number of human extracellular sialyated and/or sulfated glycans via this protein, including chondroitin sulfate, heparin and ganglioside GT3. Binds DNA non-specifically (By similarity)
The C-terminal beta-barrel forms a monomer
Cell outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6CUJ | X-ray | 1.8 Å | A/B=275-427 |
| 5O1R | X-ray | 2.86 Å | A/B=312-427 |
| 2LFU | NMR | A=245-427 |
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