Mitochondrial import receptor subunit TOM22 homolog (TOMM22) is a 142-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NS69.
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The mean pLDDT of this model is 71.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 29% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). Required for the…
Part of the translocase of the outer mitochondrial membrane (TOM complex) consisting of at least TOMM5, TOMM6, TOMM7, TOMM20, TOMM22 and TOMM40 (PubMed:18331822, PubMed:40080546). TOMM70 may also be found in the TOM complex (PubMed:18331822). The TOM complex interacts with the VDAC2 homodimer (PubMed:40080546). Upon mitochondrial depolarization, the TOM-VDAC assembly interacts with PINK1; the…
Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7VD2 | EM | 2.53 Å | C/H=1-142 |
| 7VBY | EM | 2.54 Å | C/H=1-142 |
| 9EII | EM | 2.75 Å | R/T=1-142 |
| 9JXV | EM | 2.89 Å | C/D=1-142 |
| 8XDN | EM | 2.93 Å | C/D=1-142 |
| 7CP9 | EM | 3.0 Å | G/H=1-142 |
| 9EIH | EM | 3.1 Å | Q/R/S/T=1-142 |
| 9EIJ | EM | 3.3 Å | R/T=1-142 |
| 7CK6 | EM | 3.4 Å | C/D=1-142 |
| 7VC4 | EM | 3.74 Å | C/H=1-142 |
| 7VDD | EM | 3.74 Å | C/H=1-142 |
| 8XVA | EM | 5.92 Å | C/H=1-142 |
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