Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) is a 800-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NYL2.
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The mean pLDDT of this model is 68.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994,…
Homodimer (PubMed:10924358, PubMed:26755636). Interacts with ZNF33A (PubMed:12535642). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3 (PubMed:21224381). Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20 (PubMed:21224381). Interacts with EIF2AK4/GCN2; promoting EIF2AK4/GCN2 kinase activity…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5X5O | X-ray | 1.87 Å | A=5-309 |
| 6JUU | X-ray | 1.9 Å | A=5-309 |
| 6JUT | X-ray | 2.1 Å | A=5-309 |
| 7YAW | X-ray | 2.1 Å | A/B/C/D=5-309 |
| 5HES | X-ray | 2.14 Å | A/B=5-309 |
| 9RPV | EM | 2.35 Å | N1/N2=1-800 |
| 7YAZ | X-ray | 2.54 Å | A=5-309 |
| 9RSX | EM | 2.91 Å | N2=1-800 |
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