Triggering receptor expressed on myeloid cells 2 (TREM2) is a 230-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NZC2.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2,…
Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XDS | X-ray | 1.47 Å | A=17-135 |
| 5UD8 | X-ray | 1.8 Å | A/B=19-130 |
| 9PWN | X-ray | 1.8 Å | A=131-148 |
| 8T51 | X-ray | 1.9 Å | E/F=148-164 |
| 8T59 | X-ray | 2.0 Å | E/F=148-166 |
| 5UD7 | X-ray | 2.2 Å | A/B/C/D/E/F=19-174 |
| 6B8O | X-ray | 2.2 Å | A/B/C/D/E/F=19-174 |
| 6Y6C | X-ray | 2.26 Å | A/B=19-174 |
| 6YMQ | X-ray | 3.07 Å | D000/G/H/I/J/K=19-131 |
| 5ELI | X-ray | 3.1 Å | A/B=19-133 |
| 6YYE | X-ray | 3.36 Å | A/B=19-131 |
| 9PX5 | X-ray | 3.7 Å | A=18-135 |
| 6Z0G | NMR | A=161-206 | |
| 6Z0H | NMR | A=161-206 | |
| 6Z0I | NMR | A=161-206 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.