Q9P0U1: Mitochondrial import receptor subunit TOM7 homolog (TOMM7)

Mitochondrial import receptor subunit TOM7 homolog (TOMM7) is a 55-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9P0U1.

Gene
TOMM7
Organism
Homo sapiens
Length
55 residues
Mean pLDDT
92.8
Model
AF-Q9P0U1-F1 v6
Model created
1 Aug 2025
PDB structures
12

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Model confidence (pLDDT)

The mean pLDDT of this model is 92.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate87%
70 to 90Confident: backbone generally right9%
50 to 70Low: treat with caution4%
Below 50Very low: often disordered regions0%

What pLDDT means and how to read it

Function

Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546)

Subunit structure

Part of the translocase of the outer mitochondrial membrane (TOM complex) consisting of at least TOMM5, TOMM6, TOMM7, TOMM20, TOMM22 and TOMM40 (PubMed:12198123, PubMed:18331822, PubMed:40080546). TOMM70 may also be found in the TOM complex (PubMed:18331822). The TOM complex interacts with the VDAC2 homodimer (PubMed:40080546). Upon mitochondrial depolarization, the TOM-VDAC assembly interacts…

Subcellular location

Mitochondrion outer membrane

Disease associations

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
7VD2EM2.53 ÅG/J=1-55
7VBYEM2.54 ÅG/J=1-55
9EIIEM2.75 ÅN/X=1-55
9JXVEM2.89 ÅG/H=1-55
8XDNEM2.93 ÅG/H=1-55
7CP9EM3.0 ÅE/F=1-55
9EIHEM3.1 ÅM/N/W/X=1-55
9EIJEM3.3 ÅN/X=1-55
7CK6EM3.4 ÅG/H=1-55
7VC4EM3.74 ÅG/J=1-55
7VDDEM3.74 ÅG/J=1-55
8XVAEM5.92 ÅG/J=1-55

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