Leucine-rich repeat protein SHOC-2 (SHOC2) is a 582-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UQ13.
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The mean pLDDT of this model is 87.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the…
Component of the SHOC2-MRAS-PP1c (SMP) complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (either PPP1CA, PPP1CB or PPP1CC) (PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS; these interactions…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T7A | X-ray | 1.79 Å | A/B=88-581 |
| 7TYG | X-ray | 1.9 Å | A/B=80-582 |
| 7TXH | X-ray | 1.95 Å | B/E=80-582 |
| 9BTN | X-ray | 2.04 Å | A=80-582 |
| 7TVF | X-ray | 2.17 Å | A/D=2-582 |
| 9BTP | X-ray | 2.37 Å | A=80-582 |
| 7TVG | X-ray | 2.4 Å | D=59-564 |
| 9OVJ | X-ray | 2.68 Å | A=80-582 |
| 9BTM | X-ray | 2.73 Å | B=80-582 |
| 7UPI | EM | 2.89 Å | C=1-582 |
| 7SD0 | EM | 2.95 Å | A=2-582 |
| 9O65 | EM | 3.0 Å | A=1-582 |
| 7SD1 | X-ray | 3.19 Å | A/B/C/D=2-582 |
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