GRB2-associated-binding protein 2 (GAB2) is a 676-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UQC2.
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The mean pLDDT of this model is 51.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 66% |
What pLDDT means and how to read it
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis
Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with…
Cytoplasm, Cell membrane, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y3R | X-ray | 1.5 Å | P=387-398 |
| 2VWF | X-ray | 1.58 Å | B=508-522 |
| 2W0Z | X-ray | 1.7 Å | B=350-358 |
| 5EXA | X-ray | 1.95 Å | C/D=387-397 |
| 6Y3S | X-ray | 1.95 Å | P=205-214 |
| 5EWZ | X-ray | 2.34 Å | C=387-395, D=207-212 |
| 6ZVD | X-ray | 2.5 Å | P=386-398 |
| 6ZVB | X-ray | 2.51 Å | P=386-398 |
| 6ZVC | X-ray | 2.51 Å | P=386-398 |
| 6ZVE | X-ray | 2.51 Å | P=386-398 |
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