SH3 and multiple ankyrin repeat domains protein 1 (Shank1) is a 2167-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9WV48.
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The mean pLDDT of this model is 47.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 71% |
What pLDDT means and how to read it
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function
May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9. Interacts with HOMER1 and HOMER3 (PubMed:19345194)
Cytoplasm, Synapse, Postsynaptic density
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1Q3O | X-ray | 1.8 Å | A/B=654-762 |
| 7A9B | X-ray | 2.0 Å | A/B=654-763 |
| 1Q3P | X-ray | 2.25 Å | A/B=654-762 |
| 3QJM | X-ray | 2.31 Å | A/B=654-768 |
| 3QJN | X-ray | 2.71 Å | A/B/C/D/E/F/G/H=654-768 |
| 3L4F | X-ray | 2.8 Å | D=653-765 |
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