Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) is a 285-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y275.
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The mean pLDDT of this model is 78.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response
Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1KXG | X-ray | 2.0 Å | A/B/C/D/E/F=134-285 |
| 5Y9J | X-ray | 2.05 Å | A=134-285 |
| 4ZCH | X-ray | 2.43 Å | A/B=140-285 |
| 1OQE | X-ray | 2.5 Å | A/B/C/D/E/F/G/H/I/J=142-285 |
| 8ZUJ | EM | 2.58 Å | D/E/F/J/K/L/P/Q/R/V/W/X/b/c/d=134-285 |
| 1OQD | X-ray | 2.6 Å | A/B/C/D/E/F/G/H/I/J=142-285 |
| 1KD7 | X-ray | 2.8 Å | A/B/C/K/L/M=126-285 |
| 6FXN | X-ray | 2.9 Å | A/B/C/J/K/L=134-285 |
| 1JH5 | X-ray | 3.0 Å | A/B/C/D/E/F/G/H/I/J=142-285 |
| 1OSG | X-ray | 3.0 Å | A/B/C/D/E/F=82-285 |
| 3V56 | X-ray | 3.0 Å | A/B/C/D/E/F=82-285 |
| 4V46 | X-ray | 3.3 Å | A0/A1/A2/A3/A4/A5/A6/A7/A8/A9/AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/AS/AT=138-285 |
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