Potassium voltage-gated channel subfamily E member 3 (KCNE3) is a 103-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y6H6.
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The mean pLDDT of this model is 71.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 44% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:10646604, PubMed:11207363, PubMed:12954870). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:12954870). Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (PubMed:11207363). Association with KCNQ1/KCLQT1 alpha subunit may form…
Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNC4/Kv3.4 (PubMed:11207363). Interacts with KCNQ1; associates with a KCNQ1:KCNE3 stoichiometry of 4:4; produces a current with nearly instantaneous activation with a linear current-voltage relationship and alters membrane raft localization; affects KCNQ1 structure and gating properties (By similarity) (PubMed:20533308,…
Cell membrane, Cytoplasm, Perikaryon, Cell projection, dendrite, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6V00 | EM | 3.1 Å | C/F/I/L=1-103 |
| 6V01 | EM | 3.9 Å | C/F/I/L=1-103 |
| 9WD8 | EM | 3.9 Å | C/F/I/L=1-103 |
| 2NDJ | NMR | A=1-103 |
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