9WD8: Human KCNQ1-KCNE3-CaM complex with two PIP2

structure of human KCNQ1-KCNE3-CaM complex with two PIP2. Determined by electron microscopy at 3.9 Å resolution. Released 3 Sept 2025.

Method
Electron microscopy
Resolution
3.9 Å
Organism
Homo sapiens
Chains
12
Atoms
15,660
Mol. weight
372.32 kDa
Ligands
CA, A1BBG
Released
3 Sept 2025

Explore 9WD8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WD8 contains 116 α-helices and 8 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, D, G and J: 17 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix105-11410
α-helix120-14223
α-helix154-17623
α-helix189-1913
α-helix193-1953
α-helix197-21519
α-helix228-2358
α-helix236-2383
α-helix248-25710
α-helix259-28325
β-strand28811
β-strand29411
α-helix299-31012
α-helix323-35432
α-helix358-37215
α-helix375-3828
α-helix510-53021
α-helix552-5554
α-helix557-5615
Chains B, E, H and K: 11 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix13-175
α-helix30-4011
α-helix46-505
α-helix52-565
α-helix69-735
α-helix84-918
α-helix103-1108
α-helix116-1183
α-helix119-1257
α-helix139-1435
α-helix146-1483
Chains C, F, I and L: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix58-8023

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Calmodulin-1B, E, H, Kprotein149Homo sapiensP0DP23 (AlphaFold model)
Potassium voltage-gated channel subfamily E member 3C, F, I, Lprotein106Homo sapiensQ9Y6H6 (AlphaFold model)
Potassium voltage-gated channel subfamily KQT member 1A, D, G, Jprotein546Homo sapiensP51787 (AlphaFold model)
Sequence of entity 1 (B, E, H, K), FASTA
>9WD8_1 Calmodulin-1 (chains B, E, H, K)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Sequence of entity 2 (C, F, I, L), FASTA
>9WD8_2 Potassium voltage-gated channel subfamily E member 3 (chains C, F, I, L)
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMY
ILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMISNS
Sequence of entity 3 (A, D, G, J), FASTA
>9WD8_3 Potassium voltage-gated channel subfamily KQT member 1 (chains A, D, G, J)
MASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVL
VCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFA
RKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSV
VFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIG
YGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASL
IQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPG
EKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGE
TLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMV
RIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLH
QLLSLH

Ligands and cofactors

IDNameFormulaCopies
CACalcium ionCa8
A1BBG(2R)-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy…C45 H85 O19 P38

Primary citation

Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function. Cui, C., Zhao, L., Kermani, A.A. et al. Cell Res (2025) 35:876-886. DOI 10.1038/s41422-025-01152-1 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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