structure of human KCNQ1-KCNE3-CaM complex with PIP2. Determined by electron microscopy at 3.9 Å resolution. Released 4 Dec 2019.
Explore 6V01 in 3D Show helices and sheets RCSB PDB PDBe
6V01 contains 128 α-helices and 8 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 105-108 | 4 | |
| α-helix | 110-114 | 5 | |
| α-helix | 120-127 | 8 | |
| α-helix | 130-141 | 12 | |
| α-helix | 154-176 | 23 | |
| α-helix | 189-191 | 3 | |
| α-helix | 193-195 | 3 | |
| α-helix | 197-215 | 19 | |
| α-helix | 228-235 | 8 | |
| α-helix | 236-238 | 3 | |
| α-helix | 248-257 | 10 | |
| α-helix | 259-283 | 25 | |
| β-strand | 288 | 1 | 2 |
| β-strand | 294 | 1 | 2 |
| α-helix | 299-310 | 12 | |
| α-helix | 323-354 | 32 | |
| α-helix | 358-372 | 15 | |
| α-helix | 375-382 | 8 | |
| α-helix | 510-530 | 21 | |
| α-helix | 552-555 | 4 | |
| α-helix | 557-561 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 13-17 | 5 | |
| α-helix | 30-40 | 11 | |
| α-helix | 46-50 | 5 | |
| α-helix | 52-56 | 5 | |
| α-helix | 69-73 | 5 | |
| α-helix | 84-91 | 8 | |
| α-helix | 103-110 | 8 | |
| α-helix | 116-118 | 3 | |
| α-helix | 119-125 | 7 | |
| α-helix | 139-143 | 5 | |
| α-helix | 146-148 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 58-73 | 16 | |
| α-helix | 77-80 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calmodulin-1 | B, E, H, K | protein | 149 | Homo sapiens | P0DP23 (AlphaFold model) |
| Potassium voltage-gated channel subfamily E member 3 | C, F, I, L | protein | 103 | Homo sapiens | Q9Y6H6 (AlphaFold model) |
| Potassium voltage-gated channel subfamily KQT member 1 | A, D, G, J | protein | 557 | Homo sapiens | P51787 (AlphaFold model) |
>6V01_1 Calmodulin-1 (chains B, E, H, K) MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
>6V01_2 Potassium voltage-gated channel subfamily E member 3 (chains C, F, I, L) METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMY ILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
>6V01_3 Potassium voltage-gated channel subfamily KQT member 1 (chains A, D, G, J) MASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVL VCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFA RKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSV VFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIG YGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASL IQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPG EKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGE TLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMV RIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLH QLLSLHSNSLEVLFQGP
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 8 |
| PT5 | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4… | C47 H85 O19 P3 | 4 |
Structural Basis of Human KCNQ1 Modulation and Gating. Sun, J., MacKinnon, R. Cell (2020) 180:340-347.e9. DOI 10.1016/j.cell.2019.12.003 · PubMed
Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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