11HE: 60S ribosomal protein L8

Rabbit 60S ribosomal subunit with eEF2 domain IV closed. Determined by electron microscopy at 2.86 Å resolution. Released 2 Sept 2026.

Method: Electron microscopy
Resolution: 2.86 Å
Organism: Oryctolagus cuniculus
Chains: 50
Atoms: 147,611
Mol. weight: 4271.13 kDa
Ligands: ZN, GDP
Released: 2 Sept 2026

Explore 11HE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

11HE contains 408 α-helices and 403 β-strands across 46 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 10: 6 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	11	1	46
α-helix	15-16	2
β-strand	18	1	47
α-helix	26-29	4
β-strand	35-37	3	48
β-strand	48-54	7	48
β-strand	58	1	46
β-strand	59-61	3	47
α-helix	62-80	19
β-strand	85-89	5	48
β-strand	95-99	5	47
β-strand	121-128	8	47
β-strand	134-140	7	48
α-helix	145-156	12
β-strand	163-167	5	48
β-strand	170	1	49
β-strand	177	1	49
α-helix	178-186	9
β-strand	190-193	4	50
β-strand	196-199	4	50
α-helix	206-212	7

Chain 11: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	16-25	10	52
α-helix	31-44	14
β-strand	49-52	4	52
β-strand	57	1	53
β-strand	62	1	53
β-strand	67-74	8	52
α-helix	76-89	14
β-strand	93-95	3	54
α-helix	96-98	3
β-strand	99	1	52
β-strand	105-109	5	52
α-helix	113-115	3
α-helix	117-119	3
β-strand	128-135	8	52
α-helix	139-143	5
α-helix	157-158	2
α-helix	159-170	12
β-strand	173-175	3	54

Chain 13: 9 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	22-24	3	55
α-helix	28-45	18
β-strand	55	1	56
β-strand	58-60	3	57
β-strand	70-72	3	57
β-strand	76	1	58
α-helix	78-84	7
α-helix	88-91	4
β-strand	96	1	56
β-strand	98	1	58
β-strand	106	1	59
α-helix	107-123	17
β-strand	124-126	3	60
β-strand	130	1	61
β-strand	133	1	61
α-helix	139-140	2
α-helix	141-146	6
β-strand	167	1	62
α-helix	168-170	3
α-helix	171-175	5
α-helix	178-210	33

Chain 14: 4 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	64
β-strand	11-15	5	65
β-strand	24-30	7	65
β-strand	35-40	6	65
β-strand	45-51	7	65
β-strand	55-61	7	65
α-helix	70-80	11
α-helix	82-88	7
α-helix	90-102	13
α-helix	106-138	33

Chain 15: 11 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-10	8
α-helix	17-32	16
β-strand	36-38	3	68
α-helix	45-51	7
β-strand	59-67	9	68
α-helix	84-86	3
α-helix	98-109	12
β-strand	114-123	10	68
β-strand	127-135	9	68
α-helix	140-144	5
α-helix	154-156	3
α-helix	159-162	4
α-helix	166-172	7
α-helix	178-183	6
α-helix	188-195	8
β-strand	198-200	3	55

Chain 17: 8 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	14-22	9	75
α-helix	26-36	11
β-strand	40	1	75
α-helix	41-52	12
β-strand	58-59	2	76
β-strand	69	1	77
α-helix	71-76	6
β-strand	80	1	77
β-strand	81-82	2	76
α-helix	85-105	21
α-helix	109-111	3
β-strand	112-121	10	75
α-helix	122-125	4
β-strand	128-130	3	78
α-helix	132-134	3
β-strand	136-138	3	78
β-strand	144-152	9	75

Chain 19: 11 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-15	11
α-helix	19-21	3
β-strand	22-24	3	85
α-helix	29-33	5
α-helix	38-47	10
β-strand	50-52	3	85
α-helix	53-57	5
α-helix	61-71	11
α-helix	78-80	3
α-helix	85-88	4
α-helix	91-111	21
α-helix	117-128	12
α-helix	135-159	25

Chain 20: 7 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	8-16	9	87
α-helix	17-18	2
α-helix	25-27	3
β-strand	28-34	7	87
α-helix	37-51	15
β-strand	59-66	8	87
α-helix	67-69	3
β-strand	76-82	7	88
β-strand	85	1	89
β-strand	90	1	89
β-strand	93-99	7	88
α-helix	102-117	16
β-strand	126-132	7	88
α-helix	140-143	4
β-strand	151-152	2	64
β-strand	168	1	72
α-helix	171-172	2

38 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
5.8S rRNA	58	RNA	156	Oryctolagus cuniculus
5S rRNA	5	RNA	120	Oryctolagus cuniculus
60S ribosomal protein L8	L8	protein	345	Oryctolagus cuniculus
60S ribosomal protein L3	L3	protein	394	Oryctolagus cuniculus	G1TL06 (AlphaFold model)
60S ribosomal protein L4	L4	protein	362	Oryctolagus cuniculus	A0A5F9DCT1 (AlphaFold model)
60S ribosomal protein L5	L5	protein	293	Oryctolagus cuniculus	P19949 (AlphaFold model)
large ribosomal subunit protein eL6	L6	protein	347	Oryctolagus cuniculus
60S ribosomal protein L7	L7	protein	225	Oryctolagus cuniculus	G1SV32 (AlphaFold model)
Large ribosomal subunit protein eL8	aa	protein	240	Oryctolagus cuniculus
60S ribosomal protein L9	L9	protein	190	Oryctolagus cuniculus	G1SWI6
Ribosomal protein L10	10	protein	213	Oryctolagus cuniculus	B7NZQ2
60S ribosomal protein L11	11	protein	170	Oryctolagus cuniculus	G1TUB8

38 more molecules are not listed.

Sequence of entity 1 (58), FASTA

>11HE_1 5.8S rRNA (chains 58)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU

Sequence of entity 2 (5), FASTA

>11HE_2 5S rRNA (chains 5)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU

Sequence of entity 3 (L8), FASTA

>11HE_3 60S ribosomal protein L8 (chains L8)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKENNRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAM
NPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGT

Sequence of entity 4 (L3), FASTA

>11HE_4 60S ribosomal protein L3 (chains L3)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKD

Sequence of entity 5 (L4), FASTA

>11HE_5 60S ribosomal protein L4 (chains L4)
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQ
TSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKR
YAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIK
KVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKLA
PGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRA
LRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAAK
SD

Sequence of entity 6 (L5), FASTA

>11HE_6 60S ribosomal protein L5 (chains L5)
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIIC
QIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQ
VEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPG
YDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKK
AHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA

Sequence of entity 7 (L6), FASTA

>11HE_7 large ribosomal subunit protein eL6 (chains L6)
MAGEKAPAAKPDATKKSPAKKADHARGKAKKKTLAEKKPKKGKPHCSRNPVLVRGIGRYS
RSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVGGDKNGGTRVVKLRKMPRYYP
TEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLSSGLLLVTG
PLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEK
EKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVFYFKKKKKYE
ITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVF

Sequence of entity 8 (L7), FASTA

>11HE_8 60S ribosomal protein L7 (chains L7)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNTLIARSLGKYNIICMEDLIHEIYTVGKHFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN

Sequence of entity 9 (aa), FASTA

>11HE_9 Large ribosomal subunit protein eL8 (chains aa)
VVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQV
LDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTL
VENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCILKGKARLGRLVHRKTCTTVAFTQ
VNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

Sequence of entity 10 (L9), FASTA

>11HE_10 60S ribosomal protein L9 (chains L9)
MKTILSNQTVDIPENVDISLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA

Sequence of entity 11 (10), FASTA

>11HE_11 Ribosomal protein L10 (chains 10)
GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLS
SEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGK
PQGTVARVHIGQVIMSIRTKLQNKEHVVEALRRAKFKFPGRQKIHISKKWGFTKFNADEF
EDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS

Sequence of entity 12 (11), FASTA

>11HE_12 60S ribosomal protein L11 (chains 11)
KENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEK
IAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYG
LDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPG

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	3
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	1

Primary citation

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles. Seraj, Z., Zottig, X., Huang, C. et al. Elife (2026) 15. DOI 10.7554/eLife.110114 · PubMed

Other PDB entries of the same protein (UniProt G1TL06 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7O7Y 2.2 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
7OYD 2.3 Å, Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b
11IQ 2.4 Å, Rabbit 80S with eEF2,eIF5A and SERBP1
7O7Z 2.4 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
8SCB 2.5 Å, Terminating ribosome with SRI-41315
9MR4 2.65 Å, NAC: Ribosome nascent chain complex(Oxa1L)
9RHU 2.65 Å, Rabbit 80S ribosome in complex with eRF1-AAQ, stalled at the Stop codon in mutated F2A…
8RJB 2.69 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8VVQ 2.7 Å, Codon sampling state of elongation inhibitor-treated mammalian ribosomes obtained from…
8RJD 2.79 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8B6C 2.79 Å, Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative…
6SGC 2.8 Å, Rabbit 80S ribosome stalled on a poly(A) tail

Browse structure collections

About this viewer

MolViewer shows 11HE directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.