11RL: Origin recognition complex subunit 2
CryoEM structure of the human origin recognition complex with DNA and CDC6 protein. Determined by electron microscopy at 2.8 Å resolution. Released 30 Sept 2026.
- Method
- Electron microscopy
- Resolution
- 2.8 Å
- Organisms
- Homo sapiens, DNA molecule
- Chains
- 8
- Atoms
- 21,274
- Mol. weight
- 448.83 kDa
- Ligands
- ATP, MG
- Released
- 30 Sept 2026
Explore 11RL in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
11RL contains 155 α-helices and 59 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 27 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 474-475 | 2 | |
| β-strand | 476 | 1 | 5 |
| α-helix | 477 | 1 | |
| α-helix | 480-484 | 5 | |
| α-helix | 487-495 | 9 | |
| α-helix | 508-523 | 16 | |
| β-strand | 528-534 | 7 | 7 |
| α-helix | 540-556 | 17 | |
| β-strand | 563-569 | 7 | 7 |
| α-helix | 570-572 | 3 | |
| α-helix | 576-578 | 3 | |
| α-helix | 579-587 | 9 | |
| α-helix | 594-606 | 13 | |
| β-strand | 614-620 | 7 | 7 |
| α-helix | 622-625 | 4 | |
| α-helix | 631-638 | 8 | |
| α-helix | 639-641 | 3 | |
| β-strand | 647-652 | 6 | 7 |
| α-helix | 658-661 | 4 | |
| α-helix | 665-671 | 7 | |
| β-strand | 675-678 | 4 | 7 |
| α-helix | 679-681 | 3 | |
| α-helix | 683-693 | 11 | |
| β-strand | 700 | 1 | 8 |
| α-helix | 702-715 | 14 | |
| α-helix | 719-735 | 17 | |
| β-strand | 746 | 1 | 8 |
| α-helix | 748-758 | 11 | |
| α-helix | 763-768 | 6 | |
| α-helix | 772-788 | 17 | |
| β-strand | 792-794 | 3 | 9 |
| α-helix | 795-809 | 15 | |
| α-helix | 811-813 | 3 | |
| α-helix | 816-828 | 13 | |
| β-strand | 832-833 | 2 | 9 |
| α-helix | 837-842 | 6 | |
| β-strand | 844-847 | 4 | 9 |
| α-helix | 851-857 | 7 | |
Chain B: 18 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 269-277 | 9 | |
| α-helix | 279-281 | 3 | |
| α-helix | 284-292 | 9 | |
| α-helix | 295-297 | 3 | |
| α-helix | 298-306 | 9 | |
| β-strand | 310-314 | 5 | 1 |
| α-helix | 320-329 | 10 | |
| β-strand | 336-339 | 4 | 1 |
| α-helix | 348-354 | 7 | |
| α-helix | 355-359 | 5 | |
| α-helix | 369-382 | 14 | |
| β-strand | 388-392 | 5 | 1 |
| α-helix | 403-413 | 11 | |
| β-strand | 418-424 | 7 | 1 |
| α-helix | 429-432 | 4 | |
| α-helix | 435-441 | 7 | |
| β-strand | 443-447 | 5 | 1 |
| α-helix | 464-467 | 4 | |
| α-helix | 474-482 | 9 | |
| α-helix | 486-501 | 16 | |
| β-strand | 511-512 | 2 | 2 |
| α-helix | 513-522 | 10 | |
| α-helix | 529-541 | 13 | |
| β-strand | 546-548 | 3 | 2 |
| β-strand | 556-558 | 3 | 2 |
| α-helix | 563-572 | 10 | |
Chain C: 36 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-13 | 4 | 1 |
| α-helix | 26-30 | 5 | |
| α-helix | 40-65 | 26 | |
| α-helix | 67-85 | 19 | |
| α-helix | 98-99 | 2 | |
| β-strand | 100-106 | 7 | 10 |
| α-helix | 111-128 | 18 | |
| β-strand | 133-136 | 4 | 10 |
| α-helix | 138-140 | 3 | |
| α-helix | 144-157 | 14 | |
| α-helix | 181-192 | 12 | |
| β-strand | 215-219 | 5 | 10 |
| α-helix | 227-238 | 12 | |
| β-strand | 246-252 | 7 | 10 |
| α-helix | 258-262 | 5 | |
| α-helix | 265-268 | 4 | |
| β-strand | 271-277 | 7 | 10 |
| α-helix | 278-280 | 3 | |
| α-helix | 281-292 | 12 | |
| β-strand | 301-302 | 2 | 11 |
| α-helix | 304-313 | 10 | |
| α-helix | 314-318 | 5 | |
| α-helix | 321-338 | 18 | |
| α-helix | 340-344 | 5 | |
| α-helix | 348-356 | 9 | |
| α-helix | 360-367 | 8 | |
| α-helix | 370-376 | 7 | |
| α-helix | 381-389 | 9 | |
| α-helix | 391-425 | 35 | |
| α-helix | 435-443 | 9 | |
| α-helix | 451-460 | 10 | |
| α-helix | 465-481 | 17 | |
| α-helix | 488-499 | 12 | |
| α-helix | 548-566 | 19 | |
| α-helix | 570-572 | 3 | |
| α-helix | 576-578 | 3 | |
| β-strand | 580-581 | 2 | 11 |
| α-helix | 584-591 | 8 | |
| α-helix | 595-604 | 10 | |
| α-helix | 606-608 | 3 | |
| α-helix | 613-615 | 3 | |
| α-helix | 628-637 | 10 | |
| β-strand | 642-644 | 3 | 12 |
| α-helix | 645-660 | 16 | |
| α-helix | 670-690 | 21 | |
| β-strand | 693-695 | 3 | 12 |
| β-strand | 702-705 | 4 | 12 |
Chain D: 24 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-25 | 13 | |
| α-helix | 26-30 | 5 | |
| α-helix | 41-57 | 17 | |
| β-strand | 61-66 | 6 | 3 |
| α-helix | 73-86 | 14 | |
| β-strand | 95-100 | 6 | 3 |
| α-helix | 107-118 | 12 | |
| β-strand | 123-124 | 2 | 4 |
| β-strand | 127-128 | 2 | 4 |
| α-helix | 132-144 | 13 | |
| β-strand | 151 | 1 | 5 |
| α-helix | 152-153 | 2 | |
| β-strand | 154-159 | 6 | 3 |
| α-helix | 161-165 | 5 | |
| α-helix | 168-170 | 3 | |
| α-helix | 171-180 | 10 | |
| β-strand | 187-193 | 7 | 3 |
| α-helix | 198-201 | 4 | |
| α-helix | 204-209 | 6 | |
| β-strand | 214-216 | 3 | 3 |
| α-helix | 223-234 | 12 | |
| α-helix | 236-237 | 2 | |
| α-helix | 243-258 | 16 | |
| α-helix | 260-272 | 13 | |
| α-helix | 276-287 | 12 | |
| α-helix | 299-309 | 11 | |
| α-helix | 313-319 | 7 | |
| α-helix | 323-338 | 16 | |
| β-strand | 344 | 1 | 6 |
| α-helix | 346-358 | 13 | |
| α-helix | 369-381 | 13 | |
| β-strand | 385-387 | 3 | 6 |
| β-strand | 402-404 | 3 | 6 |
| α-helix | 408-416 | 9 | |
| α-helix | 423-430 | 8 | |
Chain E: 23 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-22 | 11 | |
| β-strand | 32-36 | 5 | 13 |
| α-helix | 43-53 | 11 | |
| β-strand | 58-62 | 5 | 13 |
| α-helix | 69-83 | 15 | |
| α-helix | 99-109 | 11 | |
| α-helix | 113-116 | 4 | |
| β-strand | 120-125 | 6 | 13 |
| α-helix | 127-129 | 3 | |
| α-helix | 137-142 | 6 | |
| α-helix | 144-148 | 5 | |
| β-strand | 152-158 | 7 | 13 |
| α-helix | 162-164 | 3 | |
| α-helix | 173-174 | 2 | |
| β-strand | 175-178 | 4 | 13 |
| α-helix | 180-182 | 3 | |
| α-helix | 184-193 | 10 | |
| α-helix | 201-215 | 15 | |
| α-helix | 222-236 | 15 | |
| α-helix | 238-241 | 4 | |
| α-helix | 250-265 | 16 | |
| α-helix | 304-317 | 14 | |
| α-helix | 325-329 | 5 | |
| α-helix | 349-352 | 4 | |
| β-strand | 357-358 | 2 | 14 |
| α-helix | 359-369 | 11 | |
| α-helix | 378-389 | 12 | |
| β-strand | 393-396 | 4 | 14 |
| β-strand | 406-409 | 4 | 14 |
| α-helix | 413-422 | 10 | |
| α-helix | 427-430 | 4 | |
Chain G: 27 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 156-163 | 8 | |
| α-helix | 176-190 | 15 | |
| β-strand | 196-202 | 7 | 15 |
| α-helix | 208-222 | 15 | |
| β-strand | 226-232 | 7 | 15 |
| α-helix | 239-241 | 3 | |
| α-helix | 242-249 | 8 | |
| α-helix | 261-271 | 11 | |
| β-strand | 278-284 | 7 | 15 |
| α-helix | 286-289 | 4 | |
| α-helix | 292-294 | 3 | |
| α-helix | 295-302 | 8 | |
| α-helix | 303-305 | 3 | |
| β-strand | 311-316 | 6 | 15 |
| α-helix | 322-325 | 4 | |
| α-helix | 328-332 | 5 | |
| α-helix | 337-338 | 2 | |
| β-strand | 339-343 | 5 | 15 |
| α-helix | 344-346 | 3 | |
| α-helix | 348-359 | 12 | |
| β-strand | 368 | 1 | 16 |
| α-helix | 370-383 | 14 | |
| α-helix | 387-407 | 21 | |
| α-helix | 427-428 | 2 | |
| β-strand | 429 | 1 | 16 |
| α-helix | 431-442 | 12 | |
| α-helix | 459-475 | 17 | |
| β-strand | 480-481 | 2 | 17 |
| α-helix | 482-495 | 14 | |
| α-helix | 499-502 | 4 | |
| α-helix | 503-505 | 3 | |
| α-helix | 506-515 | 10 | |
| β-strand | 519-522 | 4 | 17 |
| α-helix | 527-529 | 3 | |
| β-strand | 531-534 | 4 | 17 |
| α-helix | 538-545 | 8 | |
| α-helix | 549-556 | 8 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Origin recognition complex subunit 2 | B | protein | 577 | Homo sapiens | Q13416 (AlphaFold model) |
| Origin recognition complex subunit 4 | D | protein | 436 | Homo sapiens | O43929 (AlphaFold model) |
| DNA (29-mer) | H | DNA | 60 | DNA molecule | |
| DNA (29-mer) | I | DNA | 60 | DNA molecule | |
| Origin recognition complex subunit 1 | A | protein | 862 | Homo sapiens | Q13415 (AlphaFold model) |
| Origin recognition complex subunit 3 | C | protein | 712 | Homo sapiens | Q9UBD5 (AlphaFold model) |
| Origin recognition complex subunit 5 | E | protein | 435 | Homo sapiens | O43913 |
| Cell division control protein 6 homolog | G | protein | 561 | Homo sapiens | Q99741 |
Sequence of entity 1 (B), FASTA
>11RL_1 Origin recognition complex subunit 2 (chains B)
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED
DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS
VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE
SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV
EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK
WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL
DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL
IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV
LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR
DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
Sequence of entity 2 (D), FASTA
>11RL_2 Origin recognition complex subunit 4 (chains D)
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGES
NSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNL
ENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEF
PDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAV
DLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK
AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPN
CPTDVRQWATSSLSWL
Sequence of entity 3 (H), FASTA
>11RL_3 DNA (29-MER) (chains H)
GGGCTGCTGCTGCGGAGAGTGCGCTGGGTCTCTCCCGTGGTATGCGCGCGGGGACCATAC
Sequence of entity 4 (I), FASTA
>11RL_4 DNA (29-MER) (chains I)
GTATGGTCCCCGCGCGCATACCACGGGAGAGACCCAGCGCACTCTCCGCAGCAGCAGCCC
Sequence of entity 5 (A), FASTA
>11RL_5 Origin recognition complex subunit 1 (chains A)
GMAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDD
DENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPA
CDSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKP
QESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLEL
GNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRET
GLSYTEDDKKASPEHRIILRTRIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIK
KRDAKEAKAQNEATSTPHRIRRKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDS
SSDEEEASTPPLPRRAPRTVSRNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSL
AAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTG
KTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAE
LLAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLP
ERIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDA
RRCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLR
AILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRN
DLLLRVRLNVSQDDVLYALKDE
Sequence of entity 6 (C), FASTA
>11RL_6 Origin recognition complex subunit 3 (chains C)
GMATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENE
RLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFG
SLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHY
SMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQ
HLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFP
FKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLS
NNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCL
HKFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVF
KSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKEL
RRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIAL
HTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAA
EKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
Sequence of entity 7 (E), FASTA
>11RL_7 Origin recognition complex subunit 5 (chains E)
MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVF
VNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTV
YIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFP
DYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPV
VKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHV
ELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLD
RLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIA
RTVNFDIIKYLYDFL
Sequence of entity 8 (G), FASTA
>11RL_8 Cell division control protein 6 homolog (chains G)
GMPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLSPRKRL
GDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDNQLTIKSPSKRELAKVHQNK
ILSSVRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREM
DVIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTA
QAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYT
LFEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRL
NQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTILKPLSECKS
PSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKE
VTLGKLYEAYSKVCRKQQVAAVDQSECLSLSGLLEARGILGLKRNKETRLTKVFFKIEEK
EIEHALKDKALIGNILATGLP
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 4 |
| MG | Magnesium ion | Mg | 4 |
Primary citation
Evolution of Origin Sequence and Recognition for Licensing of Eukaryotic DNA Replication. Bauer, J., Zali, N., Chouhan, O.P. et al. To be published.
Other PDB entries of the same protein (UniProt Q13416 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5C8H 2.01 Å, Crystal structure of ORC2 C-terminal domain
- 7JPO 3.2 Å, ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH
- 7JPQ 3.5 Å, ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5
- 8S0D 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC1-6
- 7JPP 3.7 Å, ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain
- 7CTE 3.8 Å, Human Origin Recognition Complex, ORC2-5
- 8S0E 3.8 Å, H. sapiens OCCM bound to double stranded DNA
- 7JPR 4.0 Å, ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation
- 8S0C 4.0 Å, H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
- 8S0F 4.1 Å, H. sapiens OC1M bound to double stranded DNA
- 7JPS 4.4 Å, ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core
- 7CTF 4.8 Å, Human origin recognition complex 1-5 State II
Browse structure collections
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