Origin recognition complex subunit 4 (ORC4) is a 436-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43929.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 85.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7JPO | EM | 3.2 Å | D=1-436 |
| 5UJ7 | X-ray | 3.39 Å | C/D=1-436 |
| 7JPQ | EM | 3.5 Å | D=1-436 |
| 8S0D | EM | 3.6 Å | D=1-436 |
| 7JPP | EM | 3.7 Å | D=1-436 |
| 7CTE | EM | 3.8 Å | D=1-436 |
| 8S0E | EM | 3.8 Å | D=1-436 |
| 7JPR | EM | 4.0 Å | D=1-436 |
| 8S0C | EM | 4.0 Å | D=1-436 |
| 8S0F | EM | 4.1 Å | D=1-436 |
| 7JPS | EM | 4.4 Å | D=1-436 |
| 7CTF | EM | 4.8 Å | D=1-436 |
| 7CTG | EM | 5.0 Å | D=1-436 |
| 8RWV | EM | 6.68 Å | D=1-436 |
| 5UJM | EM | 18.0 Å | D=1-436 |
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