Origin recognition complex subunit 1 (ORC1) is a 861-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13415.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6P3W | X-ray | 2.54 Å | E/F=233-239 |
| 7JPO | EM | 3.2 Å | A=471-861 |
| 5UJ7 | X-ray | 3.39 Å | A/B=471-861 |
| 8S0D | EM | 3.6 Å | A=1-861 |
| 7JPP | EM | 3.7 Å | A=471-861 |
| 8S0E | EM | 3.8 Å | A=1-861 |
| 7JPR | EM | 4.0 Å | A=471-861 |
| 8S0C | EM | 4.0 Å | A=1-861 |
| 8S0F | EM | 4.1 Å | A=1-861 |
| 7JPS | EM | 4.4 Å | A=471-861 |
| 7CTF | EM | 4.8 Å | A=1-861 |
| 7CTG | EM | 5.0 Å | A=1-861 |
| 8RWV | EM | 6.68 Å | A=2-861 |
| 5UJM | EM | 18.0 Å | A=471-861 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.