1ACC: Anthrax protective antigen

Name: PDB 1ACC: Anthrax protective antigen
Published: 1998-02-11
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: toxin

Anthrax protective antigen. Determined by X-ray diffraction at 2.1 Å resolution. Released 11 Feb 1998.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Bacillus anthracis
Chains: 1
Atoms: 5,672
Mol. weight: 82.85 kDa
Ligands: CA
Released: 11 Feb 1998

Explore 1ACC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1ACC contains 25 α-helices and 58 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 58 β-strands

Element	Residues	Length	Sheet
β-strand	20-24	5	1
β-strand	32-37	6	1
β-strand	42	1	2
β-strand	45	1	3
α-helix	47-49	3
α-helix	55-58	4
β-strand	62-70	9	1
β-strand	75-77	3	4
β-strand	78-81	4	5
α-helix	84-86	3
β-strand	87-91	5	1
β-strand	94-97	4	1
β-strand	106-108	3	4
β-strand	113-121	9	1
β-strand	130	1	3
β-strand	133	1	2
β-strand	134-137	4	5
β-strand	143-145	3	5
α-helix	146-147	2
β-strand	151-152	2	1
α-helix	185-190	6
β-strand	192-196	5	1
β-strand	201-205	5	1
α-helix	208-212	5
α-helix	216-218	3
β-strand	219	1	1
α-helix	235-240	6
α-helix	249-252	4
β-strand	256	1	6
β-strand	262-273	12	7
β-strand	289-292	4	7
β-strand	293-297	5	8
α-helix	300-301	2
β-strand	302	1	9
β-strand	321	1	9
β-strand	328-334	7	8
β-strand	358-368	11	7
β-strand	374	1	10
α-helix	378-380	3
β-strand	381-385	5	8
β-strand	389-394	6	8
β-strand	405	1	10
β-strand	409-411	3	7
β-strand	419-420	2	7
α-helix	430-431	2
β-strand	432-434	3	7
α-helix	436-445	10
β-strand	447-452	6	8
β-strand	458-463	6	11
β-strand	468-476	9	11
α-helix	477-487	11
β-strand	488-493	6	6
β-strand	501-506	6	6
β-strand	508	1	12
α-helix	519-520	2
β-strand	522	1	13
α-helix	523-531	9
β-strand	534	1	14
β-strand	541-542	2	14
β-strand	545-546	2	14
α-helix	547-549	3
β-strand	550-554	5	6
α-helix	556-569	14
α-helix	575-580	6
α-helix	581	1
β-strand	582	1	13
α-helix	583	1
β-strand	584	1	12
β-strand	588-593	6	6
β-strand	597-598	2	15
β-strand	604-606	3	15
α-helix	609-614	6
β-strand	619-622	4	16
β-strand	626-629	4	16
α-helix	633-637	5
β-strand	639-647	9	17
β-strand	653-655	3	17
β-strand	666-668	3	16
β-strand	674-677	4	16
β-strand	695-702	8	17
α-helix	703-705	3
β-strand	724-730	7	17
α-helix	731-734	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Anthrax protective antigen	A	protein	735	Bacillus anthracis	P13423 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1ACC_1 ANTHRAX PROTECTIVE ANTIGEN (chains A)
EVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYF
QSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQY
QRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDN
DGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVT
GRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSETRTISKNTSTSRTHT
SEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARL
NANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIA
LNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEV
LPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNL
QYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDR
NNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRY
DMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNG
IKKILIFSKKGYEIG

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	2

Primary citation

Crystal structure of the anthrax toxin protective antigen. Petosa, C., Collier, R.J., Klimpel, K.R. et al. Nature (1997) 385:833-838. DOI 10.1038/385833a0 · PubMed

Other PDB entries of the same protein (UniProt P13423 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3TEW 1.45 Å, Crystal Structure of Anthrax Protective Antigen (Membrane Insertion Loop Deleted) to…
4H2A 1.62 Å, Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)
3MHZ 1.7 Å, 1.7A structure of 2-fluorohistidine labeled Protective Antigen
3TEX 1.7 Å, Crystal Structure of Anthrax Protective Antigen (Membrane Insertion Loop Deleted) to…
4NAM 1.7 Å, 1.7A structure of 5-Fluoro Tryptophan Labeled Protective Antigen (W206Y)
3TEZ 1.83 Å, Crystal Structure of Anthrax Protective Antigen Mutant S337C N664C and dithiolacetone…
4EE2 1.91 Å, Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution
5FR3 1.94 Å, X-ray crystal structure of aggregation-resistant protective antigen of Bacillus…
3INO 1.95 Å, 1.95A Resolution Structure of Protective Antigen Domain 4
3Q8B 2.0 Å, Crystal structure of WT Protective Antigen (pH 9.0)
3Q8E 2.1 Å, Crystal structure of Protective Antigen W346F (pH 8.5)
3Q8F 2.1 Å, Crystal structure of 2-Fluorohistine labeled Protective Antigen (pH 5.8)

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Toxins and how they work

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