1AUE: Fkbp-rapamycin associated protein

Fkbp-rapamycin binding domain (FRB) of the fkbp-rapamycin associated protein. Determined by X-ray diffraction at 2.33 Å resolution. Released 28 Oct 1998.

Method: X-ray diffraction
Resolution: 2.33 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,643
Mol. weight: 24.2 kDa
Released: 28 Oct 1998

Explore 1AUE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1AUE contains 10 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	2024-2036	13
α-helix	2037-2041	5
α-helix	2045-2060	16
α-helix	2066-2092	27
α-helix	2096-2111	16

Chain B: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	2024-2036	13
α-helix	2037-2041	5
α-helix	2045-2061	17
α-helix	2066-2092	27
α-helix	2095-2111	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Fkbp-rapamycin associated protein	A, B	protein	100	Homo sapiens	P42345 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1AUE_1 FKBP-RAPAMYCIN ASSOCIATED PROTEIN (chains A, B)
ELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAY
GRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ

Primary citation

Structural Basis for Peptidomimicry by the Effector Element of Rapamycin. Odagaki, Y., Clardy, J. J Am Chem Soc (1997) 119:10253-10254. PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR

Browse structure collections

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