Serine/threonine-protein kinase mTOR (MTOR) is a 2549-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42345.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 72% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the…
Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR (PubMed:12150925, PubMed:12150926, PubMed:12408816, PubMed:12718876, PubMed:18925875, PubMed:20542007, PubMed:23636326, PubMed:24403073, PubMed:26678875, PubMed:27909983, PubMed:29236692, PubMed:31601764, PubMed:34519268, PubMed:34519269, PubMed:36697823). The mTORC1 complex is a 1 Md obligate…
Lysosome membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Cell membrane, Mitochondrion outer membrane, Cytoplasm, Nucleus, Nucleus, PML body, Microsome membrane, Cytoplasmic vesicle, phagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DRI | X-ray | 1.45 Å | B=2025-2114 |
| 9DBO | X-ray | 1.55 Å | C=2021-2113 |
| 5GPG | X-ray | 1.67 Å | B=2021-2112 |
| 5WBH | X-ray | 1.75 Å | A/B/C/D/E=2018-2114 |
| 4DRJ | X-ray | 1.8 Å | B=2025-2114 |
| 3FAP | X-ray | 1.85 Å | B=2019-2112 |
| 8PPZ | X-ray | 1.85 Å | B=2025-2114 |
| 8XI9 | X-ray | 1.85 Å | A=2023-2114 |
| 9DL0 | X-ray | 2.0 Å | G/I=2021-2113 |
| 1NSG | X-ray | 2.2 Å | B=2019-2112 |
| 2FAP | X-ray | 2.2 Å | B=2019-2112 |
| 6M4U | X-ray | 2.2 Å | B/F=2021-2113 |
| 4DRH | X-ray | 2.3 Å | B/E=2025-2114 |
| 1AUE | X-ray | 2.33 Å | A/B=2015-2114 |
| 9T94 | EM | 2.6 Å | A=1-2549 |
| 9ZBK | EM | 2.6 Å | A=80-2549 |
| 1FAP | X-ray | 2.7 Å | B=2018-2112 |
| 4FAP | X-ray | 2.8 Å | B=2019-2112 |
| 8ER6 | X-ray | 2.81 Å | B/D/F=2019-2112 |
| 8ERA | EM | 2.86 Å | A=1-2549 |
Showing 20 of 70 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.