1BP3: Protein

The xray structure of a growth hormone-prolactin receptor complex. Determined by X-ray diffraction at 2.9 Å resolution. Released 19 Aug 1998.

Method: X-ray diffraction
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,123
Mol. weight: 46.86 kDa
Ligands: ZN
Released: 19 Aug 1998

Explore 1BP3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1BP3 contains 13 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	6-34	29
α-helix	41-43	3
α-helix	48-51	4
α-helix	54-56	3
α-helix	64-67	4
α-helix	72-85	14
α-helix	89-91	3
α-helix	94-98	5
α-helix	110-126	17
α-helix	155-184	30

Chain B: 3 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	207-213	7	1
β-strand	214	1	2
β-strand	220-226	7	1
β-strand	237-242	6	3
β-strand	249-250	2	3
β-strand	261-264	4	1
β-strand	274-280	7	3
β-strand	281-282	2	4
β-strand	288-289	2	4
β-strand	293-296	4	3
α-helix	297-299	3
β-strand	301	1	2
α-helix	304-306	3
β-strand	310	1	5
β-strand	314	1	6
β-strand	322	1	6
β-strand	325-326	2	5
β-strand	342-350	9	7
β-strand	357-362	6	7
β-strand	366-367	2	5
β-strand	377-386	10	7
α-helix	393-397	5
β-strand	400-401	2	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (growth hormone)	A	protein	191	Homo sapiens	P01241 (AlphaFold model)
Protein (prolactin receptor)	B	protein	211	Homo sapiens	P16471 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1BP3_1 PROTEIN (GROWTH HORMONE) (chains A)
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEER
IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV
QCRSVEGSCGF

Sequence of entity 2 (B), FASTA

>1BP3_2 PROTEIN (PROLACTIN RECEPTOR) (chains B)
QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPN
SCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRK
PYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLV
QVRCKPDHGYWSAWSPATFIQIPSDFTMNDT

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

The X-ray structure of a growth hormone-prolactin receptor complex. Somers, W., Ultsch, M., De Vos, A.M. et al. Nature (1994) 372:478-481. DOI 10.1038/372478a0 · PubMed

Other PDB entries of the same protein (UniProt P01241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1HUW 2.0 Å, The crystal structure of affinity-matured human growth hormone at 2 Å resolution
1AXI 2.1 Å, Structural plasticity at the hgh:hghbp interface
1HGU 2.5 Å, Human growth hormone
1HWG 2.5 Å, 1:2 complex of human growth hormone with its soluble binding protein
1A22 2.6 Å, Human growth hormone bound to single receptor
1KF9 2.6 Å, Phage display derived variant of human growth hormone complexed with two copies of the…
3HHR 2.8 Å, Human growth hormone and extracellular domain of its receptor: crystal structure of the…
1HWH 2.9 Å, 1:1 complex of human growth hormone mutant G120R with its soluble binding protein

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