1CFF: Calmodulin

Name: PDB 1CFF: NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump
Published: 1999-09-24
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: calmodulin

NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump. Determined by solution NMR. Released 24 Sept 1999.

Method: Solution NMR
Organisms: Xenopus laevis, Homo sapiens
Chains: 2
Atoms: 1,347
Mol. weight: 19.38 kDa
Ligands: CA
Released: 24 Sept 1999

Explore 1CFF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1CFF contains 11 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-18	13
β-strand	27	1	1
α-helix	29-38	10
α-helix	47-55	9
β-strand	63	1	1
α-helix	65-73	9
α-helix	86-92	7
β-strand	99	1	2
α-helix	103-104	2
α-helix	105-109	5
α-helix	110-111	2
α-helix	118-128	11
β-strand	137	1	2
α-helix	138-145	8

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	8-17	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Xenopus laevis	P0DP33 (AlphaFold model)
Calcium pump	B	protein	20	Homo sapiens	P23634 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1CFF_1 CALMODULIN (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>1CFF_2 CALCIUM PUMP (chains B)
LRRGQILWFRGLNRIQTQIK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump. Elshorst, B., Hennig, M., Forsterling, H. et al. Biochemistry (1999) 38:12320-12332. DOI 10.1021/bi9908235 · PubMed

Other PDB entries of the same protein (UniProt P0DP33 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1IQ5 1.8 Å, Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
2COL 2.2 Å, Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
4R8G 3.5 Å, Crystal Structure of Myosin-1c tail in complex with Calmodulin
1Y0V 3.6 Å, Crystal structure of anthrax edema factor (EF) in complex with calmodulin and…
1CFC Calcium-free calmodulin
1CFD Calcium-free calmodulin
1CKK Calmodulin/rat CA2+/CALMODULIN dependent protein kinase fragment
1DMO Calmodulin, NMR, 30 structures
1F70 Refined solution structure of calmodulin N-terminal domain
1F71 Refined solution structure of calmodulin C-terminal domain
1MUX Solution NMR structure of calmodulin/w-7 complex: the basis of diversity in molecular…
1NWD Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia…

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